Por favor, use este identificador para citar o enlazar este ítem: http://rima.ufrrj.br/jspui/handle/20.500.14407/25961
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.contributor.authorBezerra, Ramon da Luz-
dc.date.accessioned2026-08-07T14:04:29Z-
dc.date.available2026-08-07T14:04:29Z-
dc.date.issued2023-09-29-
dc.identifier.citationBEZERRA, Ramon da Luz. Atividade do Triflumuron, Diflubenzuron, e sua associação no controle de Ctenocephalides felis felis (Siphonaptera, Pulicidae). 2023. 48 f. Dissertação (Ciências Veterinárias) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2023.pt_BR
dc.identifier.urihttp://rima.ufrrj.br/jspui/handle/20.500.14407/25961-
dc.description.abstractA pulga do gato, conhecida como Ctenocephalides felis felis, representa o principal ectoparasito encontrado em cães e gatos domésticos em todo o mundo. Esses insetos desempenham um papel fundamental como vetores de importantes agentes patogênicos, e a saliva deles pode desencadear dermatite alérgica por picada de pulga. Os reguladores de crescimento de insetos, são amplamente empregados em estratégias de controle e suas combinações demonstram ser promissoras para o desenvolvimento de novas formulações. O objetivo do trabalho foi avaliar a atividade do diflubenzuron e triflumuron, estimar asconcentrações letais (CL) e avaliar a associação destes dois reguladores para as formas imaturas de C. felis felis. No presente estudo foram testadas in vitro, larvas de C. felis felis de primeiro ínstar em dois gramas de dieta larval impregnada com diflubenzuron e triflumuron em diferentes concentrações de para ambos os compostos. Após a impregnação, avaliou-se tanto a evolução do ciclo e como a emergência dos adultos desafiados no dia 28 após a impregnação. Observou-se uma atividade reguladora de 97,9% na concentração 5 ppm (5 μg/g) de diflubenzuron em larvas de 1o instar e de 100 % na concentração 10 ppm (10 μg/g) de triflumuron. As concentrações letais 50 para larvas foram de 0,370 ppm (0,370 μg/g) para diflubenzuron e de 3,45 ppm (3,45 μg/g) para triflumuron. Com bases nesses resultados, pôde se afirmar que essas benzoilfenilureias obtiveram atividade sobre as larvas de C. felis felis interferindo em seu ciclo de desenvolvimento, apresentando um efeito inibidor de emergência de adultos. Contudo, esses reguladores de crescimento não apresentaram o efeito sinérgico no controle de C. felis felis.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESpt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal Rural do Rio de Janeiropt_BR
dc.subjectlarvaspt_BR
dc.subjectcontrolept_BR
dc.subjectdisruptores de desenvolvimentopt_BR
dc.subjectbenzoilfenilureiaspt_BR
dc.subjectlarvaept_BR
dc.subjectcontrolpt_BR
dc.subjectdevelopmental disruptorspt_BR
dc.subjectbenzoylphenylureaspt_BR
dc.titleAtividade do Triflumuron, Diflubenzuron, e sua associação no controle de Ctenocephalides felis felis (Siphonaptera, Pulicidae)pt_BR
dc.title.alternativeActivity of triflumuron, diflubenzuron and association in the control of Ctenocephalides felis felis (Siphonaptera, Pulicidae)en
dc.typeDissertaçãopt_BR
dc.description.abstractOtherThe cat flea, known as Ctenocephalides felis felis, is the main ectoparasite found on domestic dogs and cats worldwide. These insects play a key role as vectors for important pathogens, and their saliva can trigger flea-bite allergic dermatitis. Insect growth regulators are widely used in control strategies and their combinations show promise for the development of new formulations. The aim of this study was to evaluate the activity of diflubenzuron and triflumuron, to calculate the estimated lethal concentrations (LC) and to evaluate the combination of these two regulators for immature forms of C. felis felis. In this study, first- stage C. felis felis larvae were tested in vitro on two grams of larval diet impregnated with diflubenzuron and triflumuron. After impregnation, the cycle was evaluated and the emergence of the challenged adults on day 28.A regulatory activity of 97.9% was observed at a concentration of 5 ppm (5 μg/g) of diflubenzuron in 1st instar larvae and 100 % at a concentration of 10 ppm (10 μg/g) of triflumuron .The lethal concentrations 50 for 1st instar larvae were 0.370 ppm (0.370 μg/g) for diflubenzuron and 3.45 ppm (3.45 μg/g) for Triflumuron .Based on these results, it can be said that these benzoylphenylureas were active on C. felis felis larvae, interfering in their development cycle and inhibiting the emergence of adults. However, these growth regulators did not have a synergistic effect on the control of C. felis felis.en
dc.contributor.advisor1Azevedo, Thaís Ribeiro Correia-
dc.contributor.advisor1IDhttps://orcid.org/0000-0003-3045-8787pt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/6049103053269712pt_BR
dc.contributor.advisor-co1Campos, Diefrey Ribeiro-
dc.contributor.advisor-co1IDhttps://orcid.org/0000-0002-5434-1463pt_BR
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/8547992443497955pt_BR
dc.contributor.referee1Azevedo, Thaís Ribeiro Correia-
dc.contributor.referee1IDhttps://orcid.org/0000-0003-3045-8787pt_BR
dc.contributor.referee1Latteshttp://lattes.cnpq.br/6049103053269712pt_BR
dc.contributor.referee2Cid, Yara Peluso-
dc.contributor.referee2IDhttps://orcid.org/0000-0003-0775-0704pt_BR
dc.contributor.referee2Latteshttp://lattes.cnpq.br/0788912635109182pt_BR
dc.contributor.referee3Martins, Isabella Vilhena Freire-
dc.contributor.referee3IDhttps://orcid.org/0000-0002-8700-3065pt_BR
dc.contributor.referee3Latteshttp://lattes.cnpq.br/6446528818006897pt_BR
dc.creator.IDhttps://orcid.org/0009-0004-1982-3362pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/1339827007586445pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Veterináriapt_BR
dc.publisher.initialsUFRRJpt_BR
dc.publisher.programPrograma de Pós-Graduação em Ciências Veterináriaspt_BR
dc.relation.referencesALZAHRANI, S. M. Evaluation of triflumuron and pyriproxyfen as alternative candidates to control house fly, Musca domestica L. (Diptera: Muscidae), in Riyadh city, Saudi Arabia. Plos One, v. 16, p. 1-11, 2021. BALDIM, J.; ALCANTARA, B.; DOMINGOS, O.; SOARES, M.; CALDAS, I.; NOVAES, R.; OLIVEIRA, T.; LAGO, J.; CHAGAS-PAULA, D. The Correlation between Chemical Structures and Antioxidant, Prooxidant, and Antitrypanosomatid Properties of Flavonoids. Oxidative Medicine and Cellular Longevity, v. 2017, p. 1-12, 2017. BELINATO, T.; MARTINS, A.; BENTO, J.; LIMA. P.; VALLE, D. Effect of triflumuron, a chitin synthesis inhibitor, on Aedes aegypti, Aedes albopictus and Culex quinquefasciatus under laboratory conditions. Parasites & Vectors, v. 6, n.83, 2013. BEUGNET, F.; MARIÉ, J. L. Emerging arthropod-borne diseases of companion animals in Europe. Veterinary Parasitology, v. 163, n. 4, p. 298-305, 2009. BEZZAR-B, R.; KILANI-M, S.; ARIBI,N. Larval exposure to azadirachtin affects fitness and oviposition site preference of Drosophila melanogaster. Pesticide Biochemistry and Physiology, v.133, p. 85-90, 2016. BLAGBURN, B.; DRYDEN, M. Biology, Treatment, and Control of Flea and Tick Infestations. Veterinary Clinics of North America - Small Animal Practice, v. 39, n.6, p.1173-1200, 2009. BLAGBURN B.; YOUNG, D.; MORAN, C.; MEYER, J.; LEIGH- HEFRON, A.; PAARLBERG, T.; ZIMMERMANN, A.; MOWREY, D.; WISEMAN, S.; SYNDER, D.. Effects of orally administered spinosad (Comfortis®) in dogs on adult and immature stages of the cat flea (Ctenocephalides felis). Veterinary Parasitology, v.168, n. 3-4, p. 312-317, 2010. BREITSCHWERDT, E.; LITTLE, S.; RUGG, D. Sarolaner-a novel isoxazoline-addresses the need for enhanced flea and tick control, Veterinary Parasitology, v.222, n.1-2 , 2016. CHAPMAN, R.; TU, C.; HARRIS, C.; HARRIS, C. Persistence Of Diflubenzuron And Bay Sir 8514 In Natural And Sterile Sandy Loam And Organic Soils. Journal of Environmental Science and Health, Part B, v. 20, n. 5, p. 489-497, 1985. CISNEROS, J.; GOULSON, D.; DERWENT, L.; PENAGOS, D.; HERNÁNDEZ, O.; WILLIAMS, T. Toxic effects of spinosad on predatory insects. Biological Control, v. 23 n. 2,p. 156-163, 2002. CRISTINA L.; OLIVEIRA B S. UFRRJ INSTITUTO DE VETERINÁRIA CURSO DE PÓS-GRADUAÇÃO EM CIÊNCIAS VETERINÁRIAS DISSERTAÇÃO Eficácia In Vitro de uma Formulação Aerossol de Piriproxifen e Ciflutrina no Controle de Ctenocephalides felis felis (Bouché, 1835) (Siphonaptera: Pulicidae), 2013. 26 DOURIS, V.; STEINBACH, D.; PANTELERI, R.; LIVADARAS, I.; PICKETT, J. A.; VAN LEEWEN, T.; NAUEN, R.; VONTAS, J. Resistance mutation conserved between insects and mites unravels the benzoylurea insecticide mode of action on chitin biosynthesis. DRUMMOND, R. O.; ERNST, S. E.; TREVINO, J. L.; GLADNEY, W. J.; GRAHAM, O. H. Boophilus annulatus and B. microplus: Laboratory tests of insecticides. Journal of Economic Entomology, v. 66, n. 1, p. 130-133, 1973. DOI: https://doi.org/10.1093/jee/66.1.130. Proceedings of the National Academy of Sciences, v. 113, n. 51, p. 14692–14697, 2016. doi:10.1073/pnas.1618258113. DRYDEN, M.; CANFIELD, M.; NIEDFELDT, E.; KINNON, A.; KALOSY, K.; SMITH, A.; FOLEY, K.; SMITH, V.; BRESS, T.; SMITH, N.; ENDRIZZI, M.; LOGIN, J. Evaluation of sarolaner and spinosad oral treatments to eliminate fleas, reduce dermatologic lesions and minimize pruritus in naturally infested dogs in west Central Florida, USA. Parasites & Vectors, v.10, n. 1, 2017. Dryden MM, Magid-Denenberg T, Bunch S: Control of fleas on naturally infested dogs and cats and in private residences with topical spot applications of fipronil or imidacloprid. Vet Parasitol. 2000, 93: 69-75. 10.1016/S0304-4017(00)00318-6. Dryden M, Carithers D, McBride A, Riggs B, Smith L, Davenport J, Smith V, Payne P, Gross S: A comparison of flea control measurement methods for tracking flea populations in highly infested private residences in Tampa FL, following topical treatment of pets with FRONTLINE® Plus (fipronil/(S)-methoprene). Intern J Appl Res Vet Med. 2011, 9 (4): 356- 567. DRYDEN, M. W.; PAYNE, P. A.; SMITH, V.; HEANEY, K.; SUN, F. Efficacy of indoxacarb applied to cats against the adult cat flea, Ctenocephalides felis, flea eggs and adult flea emergence, Parasites & Vectors, v. 6, n. 126, p.1-6, 2013. DRYDEN, M. Flea and tick control in the 21st century: Challenges and opportunities, Veterinary Dermatology, v. 20, n.5-6, p. 435-440, 2009. FERREIRA, M. M.; FIGUEIRA, M. J.; FIGUEIRA, M. J. Resistência e Inseticidas: Estratégias, Desafios e Perspectivas no Controle de Insetos, Tópicos Avançados em Entomologia Molecular Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Capitulo 15, 2012. FIGUEIREDO, A. C. P. Monografia para grau de Mestrado Integrado em Ciências Farmacêuticas, Universidade Lusofona de Humanidades e Tecnologias, p. 1-33, 2014. FISARA, P.; SARGENT, R.; SHIPSTONE, M.; VON BERKY, A.; VON BERKY, J. An open, self-controlled study on the efficacy of topical indoxacarb for eliminating fleas and clinical signs of flea-allergy dermatitis in client-owned dogs in Queensland, Australia, Veterinary Dermatology, v.25, n.3, 2014. FUKASE, T.; KAMON, M.; ITAGAKI, H. A Simulated Field Experiment with Triflumuron, a Benzoylphenylurea, Larvae of the House Fly Musca domestica in Chicken Feces, NII Eletronic Library Service, p. 93-97, 1987. 27 GAD, M.; AREF, S.; ABDELHAMID, A, Biologically active organic compounds as insect growth regulators (IGRs): introduction, mode of action, and some synthetic methods, Current Chemistry Letters, v.,10, p.393- 412 ,2021. GORDON, J. An itch to scratch. AKC Gazette v. 112, p. 52–57, 1995. GROSSCURT, A. Diflubenzuron: Some Aspects of its Ovicidal and Larvicidal Mode of Action and an Evaluation of its Practical Possibilities, Pesticide Science, v. 9, p. 373-386, 1978. GROSSCURT, A. C.; JONGSMA, B. Mode of action and insecticidal properties of diflu benzuron, Chitin and Benzoylphenyl Ureas , p. 75-99, 1986. GUPTA, R.; ANÁDON, A. Fipronil, Veterinary Toxicology: Basic and Clinical Principles: Third Edition, p. 533-538, 2018. GUPTA, R.; MILLER MUKHERJEE, I.; DOSS, R.; MALIK, J.; MILATOVIK, D. Organophosphates and carbamates, Reproductive and Developmental Toxicology, p. 609-631, 2017. HALOS, L.; LEON, W.; CHAVET-MONFRAY, K.; LARSEN, D.; BEUGNET, F. Immediate efficacy and persistent speed of kill of a novel oral formulation of afoxolaner (NexGardTM) against induced infestations with Ixodes ricinus ticks. Parasites &Vectors v. 7, p. 452, 2014. HENDERSON, G.; FOIL, L. Efficacy of Diflubenzuron in Simulated Household and Yard Conditions Against the Cat Flea Ctenocephalides felis (Bouche) (Siphonoptera: Pulicidae), Journal of Medical Entomology, v. 30, n. 3, 619- 621, 1993. HENRIQUES, B.; GENTA, F.; MELLO, C.; SILVA, L.; CODOGNO, T.; OLIVEIRA, A.; MARINHO, L.; VALLE, D.; LIMA, J.; FEDER, D.; GONZALEZ, M.; AZAMBUJA. Triflumuron Effects on the Physiology and Reproduction of Rhodnius prolixus Adult Females, BioMed Research International, v. 2016, p. 1- 12, 2016. HINK, W. F.; DROUGHT, D. C.; BARNETT, S. Effect of an experimental systemic compound, CGA-184699, on life stages of the cat flea (Siphonaptera: Pulicidae). Journal of Medical Entomology, v.28, p.424–427, 1991. HINK, W. F.; ZAKSON, M.; BARNETT, S. Evaluation of a single oral dose of lufenuron to control flea infestations in dogs. American Journal of Veterinary Research,s. 55, 822–824, 1994. KUZNER, J.; TURK, S.; GRACE, S. Confirmation of the efficacy of a novel fipronil spot-on for the treatment and control of fleas, ticks and chewing lice on dogs, Veterinary Parasitology, v.193, n.1-3, p. 245-251, 2013. LEMKE, L.; KOHLE, P.; PATTERSON, R. Susceptibility of the Cat Flea (Siphonaptera: Pulicidae) to Pyrethroids, Journal of Economic Entomology, v. 82, n. 3,1989. 28 LOPES, R.; ALVES, S. Effect of Gregarina sp. parasitism on the susceptibility of Blattella germanica to some control agents, Journal of Invertebrate Pathology, v. 88, n.3, p. 261- 264, 2005. MARSELLA, R. Advances in flea control, Veterinary Clinics of North America - Small Animal Practice, v. 29, n. 6, p.1407-1424, 1999. MASETTI, A.; DEPALO, L.; PASQUALINI, E. Impact of triflumuron on Halyomorpha halys (Hemiptera: Pentatomidae): Laboratory and field studies, Journal of Economic Entomology, v.114, n. 4, p.1709-1715, 2021. MEOLA, R.; MEIER, K.; DEAN, S.; BHASKARAN, G. Effect of pyriproxyfen in the blood diet of cat fleas on adult survival, egg viability, and larval development, Journal of Medical Entomology, v. 37, n. 4, p. 503-506, 2000. MOSER, B. A.; KOEHLER, P. G.; PATTERSON, R. S. Effect of larval diet on cat flea (Siphonaptera: Pulicidae) developmental times and adult emergence. Journal of Economic Entomology, v. 84, n. 4, p. 1257-1261, 1991. DOI: 10.1093/jee/84.4.1257. MOSER, B.; KOEHLER PATTERSON, R. Effect of Methoprene and DiHubenzuron on Larval Development of the Cat Flea (Siphonaptera: Pulicidae), Journal of Economic Entomology, v. 85, n. 1,p.112-116, 1992. Palchick S. Chemical control of vectors in: The Biolo&Y of Desae Vecton. University Prcss of Colorado, 1996. PALMAR, K.; MEOLA, S.; MEOLA, R. Mode of Action of Pyriproxyfen and Methoprene on Eggs of Ctenocephalides felis (Siphonaptera: Pulicidae), Journal of Medical Entomology, v. 30, n. 2, p. 421-426, 1993. PALMIERI, V.; DODDS, W.; MORGAN, J.; CARMEY.E.; FRITSCHE, H.; JEFFREY, J.; BULLOCK, R KIMBALL, J. Survey of canine use and safety of isoxazoline parasiticides, Veterinary Medicine and Science, v. 6, n.4, p. 933-945, 2020. RAMOS-MORALES, F. Receptor GABA A : implicaciones farmacológicas a nivel central, Archivos de Neurociencia (Mex), v. 16, n. 1, p. 40-45, 2011. RIDDIFORD, L. M.; TRUMAN, J. W. Biochemistry of Insect Hormones and Insect Growth Regulators. Biochemistry of Insects, p. 307–357, 1978. doi:10.1016/b978-0-12-591640- 0.50012-1 RUGG, D.; HAIR, J. Dose determination of a novel formulation of metaflumizone plus amitraz for control of cat fleas (Ctenocephalides felis felis) and brown dog ticks (Rhipicephalus sanguineus) on dogs, Veterinary Parasitology, v. 150, n. 3, p. 203-208, 2007. RUST, M. K. Recent advancements in the control of cat fleas, Insects, v. 11, n. 668, 2020. RUST, M. K.; REIERSON, D. A. Activity of insecticides against the preemerged adult cat flea in the cocoon (Siphonaptera: Pulicidae). Journal of Medical Entomology, v. 26, n. 4, p. 301-305, 1989. DOI: https://doi.org/10.1093/jmedent/26.4.301. 29 RUST, M.; VETTER, R.; DENHOLM, I.; BLAGBURN. B.; WILLIAMSON, M.; KOPP. S.; COLEMAN, G.; HOSTETLER, J.; DAVIS. W.; MENCKE, N.; REES, R.; FOIT, S.; TETZNER, K. Susceptibility of cat fleas (Siphonaptera: Pulicidae) to Fipronil and Imidacloprid using adult and larval bioassays, Journal of Medical Entomology, v. 51, n. 3, p. 638-643, 2014. RUST, M.; LANCE HEMSARTH, W. Synergism of adulticides and insect growth regulators against larval cat fleas (Siphonaptera: Pulicidae), Journal of Medical Entomology, v. 56, n. 3, p. 790-795, 2019. RUST, M.; HEMSARTH, W. Synergism of the IGRs methoprene and pyriproxyfen against larval cat fleas (siphonaptera: Pulicidae), Journal of Medical Entomology, v.,53. n. 3, p. 629-633, 2016. RUST, M. Insecticide resistance in fleas, Insects, v. 7, n. 1 ,2016. RUST, M. The biology and ecology of cat fleas and advancements in their pest management: A review, Insects, v. 8, n. 4, 2017. SALGADO, V.; HAYASHI, J. Metaflumizone is a novel sodium channel blocker insecticide, Veterinary Parasitology, v. 150, n. 3, p. 182-189, 2007. SEUFERER, S.; BRAYMER, H.; DUNN, J. Metabolism of Diflubenzuron by Soil Microorganisms and Mutagenicity of the Metabolites, Pesticide Biochemistry and Physiology, v. 10,p. 174 – 180, 1979. SHIPSTONE, M. A.; MASON, K.V. The use of Insect Development Inhibitors as an Oral Medication for the Control of the Fleas Ctenocephalides felis, Ct. canis in the Dog and Cat, Veterinary Dermatology, v. 6, n. 3, p. 131-137, 1995. SHONO, T.; ZHANG, L.; SCOTT, J. Indoxacarb resistance in the house fly, Musca domestica, Pesticide Biochemistry and Physiology, v.,80, n. 2, 2004. SIMON ASCHER, K.; NEMMY, N. Contact Activity of Diflubenzuron Against Spodoptera littoralis Larvae, Pesticide Science, v. 7, p. 447-452, 1976. SONG, W.; LIU, Z.; DONG, K. Molecular basis of differential sensitivity of insect sodium channels to DCJW, a bioactive metabolite of the oxadiazine insecticide indoxacarb, NeuroToxicology, v. 27, n. 2, p. 237-244, 2006. SOUZA, C. P.; VEROCAI, G. G.; SOARES, L. B.; VIEIRA. V. P. C.; TAVARES, P. V.; NUNES, T. A. P.; MAGALHÃES, V. S.; SCOTT, F. B. Eficácia da associação de d-fenotrina e piriproxifen no controle de Lynxacarus radovskyi em felinos domésticos, Revista Brasileira de Medicina Veterinária, v. 34. n. 31. p. 28-30, 2012. SU, N.; SCHEFFRAHN, R. Laboratory Evaluation of Two Chitin Synthesis Inhibitors, Hexaflumuron and Diflubenzuron, as Bait Toxicants Against Formosan and Eastern Subterranean Termites (Isoptera: Rhinotermitidae), Journal of Economic Entomology,v. 86, n. 5, p.1453-1457, 1993. 30 TAYLOR M. Recent developments in ectoparasiticides, Veterinary Journal, v. 161, n. 3, p. 253-268,2001. TORDOIR, W.; VAN SITTERT, N. Chapter 7 Organochlorines, Toxicology. v. 91, p. 51-57, 1994. WATSON, G. Actions of insecticidal spinosyns on γ-aminobutyric acid responses from small-diameter cockroach neurons, Pesticide Biochemistry and Physiology,v. 71, n. 1, p.20- 28, 2001. WAYNE YVIE, W.; WRIGHT, J. Fate of Diflubenzuron in the Stable Fly and House Fly, J. Agric, Food Chemistry, v. 26, n. 1, 1978. ZHOU, X.; HOSHMANN, A.; HSU, W. Current review of isoxazoline ectoparasiticides used in veterinary medicine, Journal of Veterinary Pharmacology and Therapeutics, v. 45, n. 1 , p. 1-15, 2022.pt_BR
dc.subject.cnpqParasitologiapt_BR
Aparece en las colecciones: Mestrado em Ciências Veterinárias

Se for cadastrado no RIMA, poderá receber informações por email.
Se ainda não tem uma conta, cadastre-se aqui!

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
2023 - RAMON DA LUZ BEZERRA.pdf1,17 MBAdobe PDFVisualizar/Abrir


Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.