Please use this identifier to cite or link to this item: https://rima.ufrrj.br/jspui/handle/20.500.14407/14196
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAbreu, Daniel Paiva Barros de
dc.date.accessioned2023-12-22T02:57:20Z-
dc.date.available2023-12-22T02:57:20Z-
dc.date.issued2017-02-20
dc.identifier.citationABREU, Daniel Paiva Barros de. Caracterização fenotípica, genotípica e perfil de sensibilidade a antifúngicos de isolados clínicos de cães e gatos pertencentes ao Complexo Sporothrix schenckii oriundos do estado do Rio de Janeiro. 2017. 82 f.. Dissertação (Mestrado em Medicina Veterinária, Patologia e Ciências Clínicas) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2017 .por
dc.identifier.urihttps://rima.ufrrj.br/jspui/handle/20.500.14407/14196-
dc.description.abstractFungos dimórficos pertencentes ao complexo Sporothrix schenckii são responsáveis pela esporotricose, importante infecção fúngica que apresenta distribuição mundial. Sua conhecida característica antropozoonótica apresenta grande relevância no estado do Rio de Janeiro, onde se verifica aumento significativo no número de pacientes humanos e animais acometidos pela doença nas últimas décadas, destacando-se em tais casos o papel do felino como agente transmissor. A descrição de novas espécies pertencentes ao gênero Sporothrix, baseada em características fenotípicas e genotípicas, demonstrou o envolvimento de outros componentes deste gênero na epidemia instalada no estado. A verificação de isolados resistentes a itraconazol, antifúngico amplamente utilizado na medicina humana e veterinária para o tratamento da doença, é fato preocupante e tem possível associação a recidivas e falhas terapêuticas. O presente estudo objetiva a identificação fenotípica e genotípica de 168 exemplares oriundos de pacientes felinos e caninos, obtidos na rotina do Diagnóstico Microbiológico Veterinário - UFRRJ, com determinação da Concentração Inibitória Mínima (CIM) frente à anfotericina B (AMB), cetoconazol (KTC), itraconazol (ITC), terbinafina (TRB) e voriconazol (VRC). A partir de características morfofisiológicas foi possível identificar 159 (94,64%) isolados como S. brasiliensis e 9 (5,36%) como S. luriei. Contudo, metodologias moleculares identificaram 168 (100%) S. brasiliensis, a partir de PCR-RFLP em gene responsável pela síntese de calmodulina. O teste de sensibilidade, realizado a partir do documento M38-A2 (CLSI) determinou maior eficácia in vitro para TRB, seguido por ITC, KTC, AMB e VRC, respectivamente. Cepas resistentes a ITC não foram detectadas no presente estudo. Tais resultados demonstram que a identificação alcançada exclusivamente por métodos fenotípicos não é recomendada para caracterização de componentes do complexo Sporothrix schenckii. Comprova-se ainda a predominância de S. brasiliensis em outras regiões do estado do RJ. A maior eficácia de TRB, somada a ausência de exemplares resistentes a ITC, reforça a necessidade de estudos farmacodinâmicos e farmacocinéticos para otimização dos protocolos terapêuticos atualmente utilizados. Obtenção de maiores informações acerca dos isolados provenientes de amostras provenientes de cães e gatos correlacionados a espécies dentro do complexo S. schenckii, bem como a avaliação da eficácia in vitro de antifúngicos proporcionam conhecimento sobre alternativas terapêuticas. Tais informações auxiliam no entendimento do quadro instalado no estado do Rio de Janeiro e fornece dados de grande utilidade para o tratamento humano e veterináriopor
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopor
dc.formatapplication/pdf*
dc.languageporpor
dc.publisherUniversidade Federal Rural do Rio de Janeiropor
dc.rightsAcesso Abertopor
dc.subjectSporothrix brasiliensiseng
dc.subjectPCR-RFLPeng
dc.subjectAntifungalseng
dc.subjectSporothrix brasiliensispor
dc.subjectPCR-RFLPpor
dc.subjectAntifúngicospor
dc.titleCaracterização fenotípica, genotípica e perfil de sensibilidade a antifúngicos de isolados clínicos de cães e gatos pertencentes ao Complexo Sporothrix schenckii oriundos do estado do Rio de Janeiropor
dc.title.alternativePhenotypic and molecular characterization and antifungal susceptibility profile of clinical isolates of Sporothrix schenckii complex obtained from dogs and cats from the state of Rio de Janeiroeng
dc.typeDissertaçãopor
dc.description.abstractOtherDimorphic fungi belonging to Sporothrix schenckii complex are responsible for sporotrichosis, important fungal infection with worldwide distribution. The anthropozoonotic characteristic is of high relevance in the state of Rio de Janeiro, where an increasing in the number of cases in human patients was observed in the last decades, highlighting the role of domestic cat as a transmitter agent. The description of new species compounding de Sporothrix genus, based on phenotypic and genotypic evaluations, showed the involvement of other members of this group in the epidemic status installed in Rio de Janeiro. The verification of strains resistant to itraconazole, a widely used antifungal in human and animal medicine for the treatment of this mycosis, is an important factor that possibly results in relapse and therapeutic failure of this disease. The present study aimed to identify, by phenotypic and molecular approaches, 168 isolates obtained from the routine of Veterinary Clinical Microbiology Laboratory – UFRRJ, and the determination of minimal inhibitory concentration (MIC) for amphotericin B (AMB), ketoconazole (KTC), itraconazole (ITC), terbinafine (TRB) and voriconazole (VRC). Based on morphophysiological characteristics it was possible to identify 159 (94.64%) isolates as S. brasiliensis and 9 (5.36%) as S. luriei. However, applying PCR-RFLP of calmodulin 168 (100%) samples were identified as S. brasilensis. The susceptibility test, based on M38-A2 document (CLSI), showed that TRB was the most effective antifungal tested, followed by ITC, KTC, AMB, and VRC, respectively. No ITC resistant isolates were detected in the present study. These results demonstrate that the identification reached only by phenotypic evaluation is not recommended for the characterization of Sporothrix schenckii complex components. It also proves the predominance of S. brasiliensis in other regions of RJ state. The better efficacy of TRB added to the absence of isolates resistant to ITC support the necessity of pharmacodynamics and pharmacokinetics studies for the optimization of the therapeutic protocols. More information about isolates from dogs and cats correlated with the species from the S. schenckii complex, as well as in vitro antifungal efficacy evaluation provide knowledge about therapeutic alternatives. In this way, the present study also provides relevant information about the endemic status in Rio de Janeiro and important data for the treatment of human and animal sporotrichosis.eng
dc.contributor.advisor1Baroni, Francisco de Assis
dc.contributor.advisor1IDCPF: 526.293.177-49por
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/5867622389423137por
dc.contributor.advisor-co1Coelho, Irene da Silva
dc.contributor.advisor-co1ID4435579693por
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/2191695584157582por
dc.contributor.referee1Pereira, Sandro Antonio
dc.contributor.referee2Cruz, Luiz Celso Hygino da
dc.creator.IDCPFD: 116.083.757-06por
dc.creator.Latteshttp://lattes.cnpq.br/7292090535824309por
dc.publisher.countryBrasilpor
dc.publisher.departmentInstituto de Veterináriapor
dc.publisher.initialsUFRRJpor
dc.publisher.programPrograma de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)por
dc.relation.referencesAHEARN, D. G.; KAPLAN, W. Occurrence of Sporotrichum schenckii on a cold-stored meat product. American Journal of Epidemiology, v. 89, p. 116-124, 1969. ALMEIDA-PAES, R.; FIGUEIREDO-CARVALHO, M. H. G.; BRITO-SANTOS, F.; ALMEIDA-SILVA, F.; OLIVEIRA, M. M. E.; ZANCOPÉ-OLIVEIRA, R. M. Melanins protect Sporothrix brasiliensis and Sporothrix schenckii from the antifungal effects of terbinafine. PLOS One, v. 11, n. 3, e0152796, 2015. ALMEIDA-PAES, R.; FRASES, S.; MONTEIRO, P. C. F.; GUTIERREZ-GALHARDO, M. C.; ZANCOPÉ-OLIVEIRA, R. M.; NOSANCHUK, J. D. Growth conditions influence melanization of Brazilian clinical Sporothrix schenckii isolates. Microbes and Infection, v. 11, n. 5, p. 554-62, 2009. ALMEIDA-PAES, R.; OLIVEIRA, M. M. E.; FREITAS, D. F. S.; VALLE, A. C. F.; ZANCOPÉ-OLIVEIRA, R. M.; GUTIERREZ-GALHARDO, M. C. Sporotrichosis in Rio de Janeiro, Brazil: Sporothrix brasiliensis is associated with atypical clinical presentations. PLOS Neglected Tropical Diseases, v. 8, n. 9, e3094, 2014 ALMEIDA-PAES, R.; OLIVEIRA, M. M. E.; FREITAS, D. F. S.; VALLE, A. C. F.; GUTIERREZ-GALHARDO, M. C.; ZANCOPÉ-OLIVEIRA, R. M. Refractory sporotrichosis due to Sporothrix brasiliensis in humans appears to be unrelated to in vivo resistance. Medical Mycology, 2016. No prelo ANDES, D. Pharmacokinetics and pharmacodynamics of antifungals. Infectious Disease Clinics of North America, v. 20, p. 679-697, 2006. ARRILLAGA-MONCRIEF, I.; CAPILLA, J.; MAYAYO, E.; MARIMON, R.; MARINÉ, M.; GENÉ, J.; KANO, J.; GUARRO, J. Different virulence levels of the species of Sporothrix in a murine model. Clinical Microbiology and Infection, v. 15, n. 7, p. 651-655, 2009. BARBEE, M. L.; TAYLOR, J. W. 18S Ribosomal RNA gene sequence characters place the human pathogen Sporothrix schenckii in the genus Ophiostoma. Experimental Mycology, v. 16, p. 87, 91, 1992. BARONI, F. A.; CAMPOS, S. G.; DIREITO, G. M. Esporotricose em gatos (Descrição de um caso). Revista Brasileira de Medicina Veterinária, v. 20, n. 1, p. 25-27, 1998. BARROS, M. B. L.; SCHUBACH, A. O.; VALLE, A. C. F.; GUTIERREZ-GALHARDO, M. C.; CONCEIÇÃO-SILVA, F; SCHUBACH, T. M. P.; REIS, R. S.; WANKE, B.; MARZOCHI, K. B. F.; CONCEIÇÃO, M. J. Cat-transmitted sporotrichosis epidemic in Rio de Janeiro, Brazil: description of a serie of cases. Clinical Infectious Disease, v, 38, p. 529- 535, 2004. BARROS, M. B. L.; ALMEIDA-PAES, R.; SCHUBACH, A. O. Sporothrix schenckii and sporotrichosis. Clinical Microbiology Reviews, v. 24, n. 4, p. 633-654, 2011. BARROS, M. B. L.; SCHUBACH, T. M. P.; GALHARDO, M. C. G.; SCHBACH, A. O.; MONTEIRO, P. C. F.; REIS, R. S.; ZANCOPÉ-OLIVEIRA, R. M.; LAZÉRA, M. S.; CUZZI-MAYA, T.; BLANCO, T. C. M.; MARZOCHI, K. B. F.; WANKE, B.; VALLE, A. C. F. Sporotrichosis: an emergent zoonosis in Rio de Janeiro. Memórias do Instituto Oswaldo Cruz, v. 96, n. 6, p. 777-779, 2001. 59 BARROS, M. B. L.; SCHUBACH, T. P.; COLL, J. O.; GREMIÃO, I. D.; WANKE, B.; SCHUBACH, A. Esporotricose: a evolução e os desafios de uma epidemia. Revista Panamericana de Salud Pública, v. 27, p. 455-460, 2010. BARTROLI, J.; TURMO, E.; ALGUÉRO, M.; BONCOMPTE, E.; VERICAT, M. L.; GARCÍA-RAFANELL, J.; FORN, J. Synthesis and antifungal activity of new azole derivates containing an N-acylmorpholine ring. Journal of Medical Chemistry, v. 38, p. 3918-3932, 1995. BAZZI, T.; MELO, S. M. P.; FIGHERA, R. A.; KOMMERS, G. D. Características clínicoepidemiológicas, histomorfológicas e histoquímicas da esporotricose felina. Pesquisa Brasileira Veterinária, v. 36, n. 4, p. 303-311, 2016. BORBA-SANTOS, L. P.; RODRIGUES, A. M.; GAGINI, T. B.; FERNANDES, G. F.; CASTRO, R.; CAMARGO, Z. P.; NUCCI, M.; LOPES-BEZERRA, L. M.; ISHIDA, K.; ROZENTAL, S. Susceptibility of Sporothrix brasiliensis isolates to amphotericin B, azoles and terbinafine. Medical Mycology, v. 53, p. 178-188, 2015. BOYCE, K. J.; ANDRIANOPOULOS, A. Fungal dimorphism: the switch from hyphae to yeast is a specialized adaptation allowing colonization of a host. FEMS Microbiology Reviews, v. 39, n. 6, p. 797-811, 2015. BRILHANTE, R. S. N.; RODRIGUES, A. M.; SIDRIM, J. J. C.; ROCHA, M. F. G.; PEREIRA, S. A.; GREMIÃO, I. D. F.; SCHUBACH, T. M. P.; CAMARGO, Z. P. In vitro susceptibility of antifungal drugs against Sporothrix brasiliensis recovered from cats with sporotrichosis in Brazil. Medical Mycology, v. 54, n. 3, p. 275-279, 2016. BUNCE, P. E.; YANG, L.; CHUN, S.; ZHANG, S. X.; TRINKAUS, M. A.; MATUKAS, L. M. Disseminated sporotrichosis in a patient with hairy cell leukemia treated with amphotericin B and posaconazole. Medical Mycology, v. 50, p. 197-201, 2012. CAMACHO, E.; LEÓN-NAVARRO, I.; RODRÍGUEZ-BRITO, S.; MENDOZA, M.; NIÑOVEJA, G. A. Molecular epidemiology of human sporotrichosis in Venezuela reveals high frequency of Sporothrix globosa. BMC Infectious Diseases, v. 15, n. 94, p. 1-10, 2015. CASADEVALL, A. Cards of virulence and the global virolume for humans. Microbe, v. 1, n. 8, p. 359-364, 2006. CHAKRABARTI, A.; BONIFAZ, A.; GUTIERREZ-GALHARDO, M. C.; MOCHIZUKI, T.; LI, S. Global epidemiology of sporotrichosis. Medical Mycology, v. 53, p. 3-14, 2015. CHAPMAN, S. W.; PAPPAS, P.; KAUFFMANN, C.; SMITH, E. B.; DIETZE, R.; TIRABOSCHI-FOSS, N.; RESTREPTO, A.; BUSTAMANTE, A. B.; OPPER, C.; EMADYAZAR, S.; BAKSHI, R. Comparative evaluation of the efficacy and safety of two doses of terbinafine (500 and 1000 mg day-1 ) in the treatment of cutaneous or lymphocutaneous sporotrichosis. Mycoses, v. 47, p. 62-68, 2004. CHARMICHAEL, J. W. Chrysosporium and some other aleuriosporic hyphomycetes. Canadian Journal of Botany, v. 40, p. 1137-1173, 1962. CHAVES, A. R.; CAMPOS, M. P.; BARROS, M. B. L.; CARMO, C. N.; GREMIÃO, I. D. F.; PEREIRA, S. A.; SCHUBACH, T. M. P. Treatment abandonment in feline sporotrichosis – Study of 147 cases. Zoonoses and Public Health, v. 60, p. 149-153, 2013 60 CHOWDHARY, G.; WEINSTEIN, A.; KLEIN, R.; MASCARENHAS, B. R. Sporotrichal arthritis. Annals of the Rheumatic Diseases, v. 50, p. 112-114, 1991. CHUA, S. S.; MOMANY, M.; MENDOZA, L.; SZANISZLO, P. J. Identification of three chitin synthase genes in the dimorphic fungal pathogen Sporothrix schenckii. Current Microbiology, v. 29, n. 3, p, 151-156, 1994. CLAVIJO-GIRALDO, D. M.; MATÍNEZ-ALVAREZ, J. A.; LOPES-BEZERRA, L. M.; PONCE-NOYOLA, P.; FRANCO, B.; ALMEIDA, R. S.; MORA-MONTES, H. M. Analysis of Sporothrix schenckii sensu stricto and Sporothrix brasiliensis virulence in Galleria mellonella. Journal of Microbiological Methods, v. 122, p. 73-77, 2016. CLSI. Clinical and Laboratory Standards Institute. Method for broth dilution antifungal susceptibility testing of filamentous fungi. 2ed. Approved standard. CLSI document M38- A2. Wayne, PA: Clinical and Laboratory Standards Institute, 2008. CONIAS, S.; WILSON, P. Epidemic cutaneous sporotrichosis: report of 16 cases in Queensland due to mouldy hay. Australasian Journal of Dermatology, v. 39, n. 1, p. 34-37, 1998. COOPER, C. R.; DIXON, D. M.; SALKIN, I. F. Laboratory-acquired sporotrichosis. Journal of Medical and Veterinary Mycology, v. 30, p. 169-171, 1992. COSTA, E. O.; DINIZ, L. S.; NETTO, C. F.; ARRUDA, C.; DAGLI, M. L. Epidemiological study of sporotrichosis and histoplasmosis in captive Latin America wild mammals, São Paulo, Brazil. Mycopathologia, v. 125, n. 1, p, 19-22, 1994. CROTHERS, S. L.; WHITE, S. D.; IHRKE, P. J.; AFFOLTER, V. K. Sporotrichosis: a retrospective evaluation of 23 cases seen in northern California (1987-2007). Veterinary Dermatology, v. 20, p. 249-259, 2009. CROUT, J. E.; BREWER, N. S.; TOMPKINS, R. B. Sporotrichosis arthritis: clinical features in seven patients. Annals of Internal Medicine, v. 86, p. 294-297, 1977. CRUZ, L. C. H. Complexo Sporothrix schenckii. Revisão da parte de literatura e considerações sobre o diagnóstico e epidemiologia. Veterinária e Zootecnia, v. 20, p. 8-28, 2013. CRUZ, L. C. H.; ROSA, C. A. R.; BAFFA, M. C.; CAMPOS, S. G. Isolamento do Sporothrix schenckii em gatos com lesões ulcerativas. In: 12º CONGRESSO BRASILEIRO DE MICROBIOLOGIA E 9º CONGRESSO LATINO-AMERICANO DE MICROBIOLOGIA, 1983, São Paulo. Anais... São Paulo: Associação Latino-Americana de Microbiologia; Sociedade Brasileira de Microbiologia, 1983. p. 124. DARKER, M. J.; SCOTT, L. J.; GOA, K. L. Terbinafine: a review of its use in onychomycosis in adults. American Journal of Clinical Dermatology, v. 4, n. 1, p. 39-65, 2003 DE ARAUJO, T. A.; MARQUES, A. C.; KERDEL, F. Sporotrichosis. International Journal of Dermatology, v. 40, p. 737-742, 2001. 61 DE BEER, Z. W.; DUONG, T. A.; WINGFIELD, M. J. The divorce of Sporothrix and Ophiostoma: solution to a problematic relationship. Studies in Mycology, v. 83, p. 165-191, 2016. DE BEER, Z. W.; HARRINGTON, T. C.; VISMER, H. F.; WINGFIELD, B. D.; WINGFIELD, M. J. Phylogeny of the Ophiostoma stenoceras-Sporothrix schenckii complex. Mycologia, v. 95, n. 3, p. 434-441, 2003. DE MEYER, E. M.; BEER, Z. W.; SUMMERBELL, R. C.; MOHARRAM, A. M.; HOOG, G. S.; VISMER, H. F.; WINGFIELD, M. J. Taxonomy and phylogeny of new wood-and soilinhabiting Sporothrix species in the Ophiostoma stenoceras-Sporothrix schenckii complex. Mycologia, v. 100, n. 4, p. 647-661, 2008. DÍAZ, I. A. C. Epidemiology of sporotrichosis in Latin America. Mycopathologia, v. 108, p. 113-116, 1989. ENGLE, J.; DESIR, J.; BERNSTEIN, J. M. A rose bt any other name. Skinmed, v. 6, n. 3, p. 139-141, 2007. FERNANDES, K. S.; MATHEWS, H. L.; BEZERRA, L. M. L. Differences in virulence of Sporothrix schenckii conidia related to culture conditions and cell-wall components. Journal of Medical Microbiology, v. 48, p. 195-203, 1999. FINDLAY, G. H. The epidemiology of sporotrichosis in the Transvaal. Medical Mycology, v. 7, n. 3, 1969. FRANCESCONI, G.; VALLE, A. C. F.; PASSOS, S. L.; BARROS, M. B. L.; PAES, R. A.; CURI, A. L. L.; LIPORAGE J.; PORTO, C. F.; GALHARDO, M. C. G. Comparative study of 250 mg/day terbinafine and 100 mg/day itraconazole for the treatment of cutaneous sporotrichosis. Mycopathologia, v. 171, p. 349-354, 2011. FRANCESCONI, G.; VALLE, A. C.; PASSOS, S.; REIS, R.; GALHARDO, M. C. Terbinafine (250 mg/day): na effective and safe treatment of cutaneous sporotrichosis. Journal of the European Academy of Dermatology and Venereology, v. 23, p. 1273-1276, 2009. FREITAS, D. C.; MIGLIANO, M. F.; ZANI-NETO, L. Esporotricose. Observação de caso espontâneo em gato doméstico (F. catus). Revista da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo, v. 5, p. 601-604, 1956. FREITAS, D. F. S.; SANTOS, S. S.; ALMEIDA-PAES, R.; OLIVEIRA, M. M. E.; VALLE, A. C. F.; GUTIERREZ-GALHARDO, M. C.; ZANCOPÉ-OLIVEIRA, R. M.; NOSANCHUK, J. Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis. Virulence, v. 6, n. 2, p. 112-120, 2015. FUKUSHIRO, R. Epidemiology and ecology of sporotrichosis in Japan. Zentralblatt für Bakteriologie Mikrobiologie und Hygiene, v. 254, p. 228-233, 1984. GEWEHR, P.; JUNG, B.; AQUINO, V.; MANFRO, R. C.; SPULDARO, F.; ROSA,. R. G.; GOLDANI, R. Z. Sporotrichosis in renal transplant patients. Canadian Journal of Infectious Diseases and Medical Microbiology, v. 24, n. 2, p. e47-e49, 2013. 62 GHOSH, A.; MAITY, P. K.; HEMASHETTAR, B. M.; SHARMA, V. K.; CHAKRABARTI, A. Physiological characters of Sporothrix schenckii isolates. Mycoses, v. 449, v. 45, p. 449- 454, 2002. GOIC, J. B.; REINEKE, E. L.; DROBATZ, K. J. Comparison of rectal and axillary temperatures in dogs and cats. Journal of the American Veterinary Medical Association, v. 244, n. 10, p. 1170-1175, 2014. GOMPERTZ, O. F.; RODRIGUES, A. M.; FERNANDES, G. F.; BENTUBO, H. D. L.; CAMARGO, Z. P.; PÉTRI, V. Case report: Atypical clinical presentation of sporotrichosis caused by Sporothrix globose resistant to itraconazole. The American Journal of Tropical Medicine and Hygiene, v. 94, n. 6, p. 1218-1222, 2016. GOTTLIEB, G. S.; LESSER, C. F.; HOLMES, K. K.; WALD, A. Disseminated sporotrichosis associated with treatment with immunosupressants and tumor necrosis factor-α antagonists. Clinical Infectious Diseases, v. 37, p. 838-840, 2003. GRAYBILL, J. R.; BURGESS, D. S.; HARDIN, T. C. Key issues concerning fungistatic versus fungicidal drugs. European Journal of Clinical Microbiology & Infectious Disease, v. 16, n. 1, p. 42-50, 1997. GREER, N. D. Voriconazole: the newest triazole antifungal agent. Pharmacology Notes, v. 16, p. 241-248, 2003. GREMIÃO, I. D. F.; MENEZES, R. C.; SCHUBACH, T. M. P.; FIGUEIREDO, A. B. F.; CAVALCANTI, M. C. H.; PEREIRA, S. A. Feline sporotrichosis: epidemiological and clinical aspects. Medical Mycology, v. 53, n. 1, p. 15-21, 2014. GREMIÃO, I. D. F.; MIRANDA, L. H. M.; REIS, E. G.; RODRIGUES, A. M.; PEREIRA, S. A. Zoonotic epidemic of sporotrichosis: cat to human transmission. PLOS Pathogens, v. 13, n. 1, e1006077, 2017. GREMIÃO, I. D. F.; PEREIRA, S. A.; RODRIGUES, A. M.; FIGUEIREDO, F. B.; JUNIOR, A. N.; SANTOS, I. B.; SCHUBACH, T. M. P. Tratamento cirúrgico associado à terapia antifúngica convencional na esporotricose felina. Acta Scientiae Veterinariae, v. 34, n. 2, p. 221-223, 2006. GREMIÃO, I. D. F.; SCHUBACH, T. M. P.; PEREIRA, S. A.; RODRIGUES, A. M.; HONSE, C. O.; BARROS, M. B. L. Treatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazole. Australian Veterinary Journal, v. 89, p. 346-351, 2011. GREMIÃO, I. D. F.; SCHUBACH, T. M. P.; PEREIRA, S. A.; RODRIGUES, A. M.; CHAVES, A. R.; BARROS, M. B. L. Intralesional amphotericin B in a cat with refractory localized sporotrichosis. Journal of Feline Medicine and Surgery, v. 11, p. 720-723, 2009. GROLL, A.; KOLVE, H. Antifungal agents: In vitro susceptibility testing, pharmacodynamics, and prospects for combination therapy. European Journal of Clinical Microbiology & Infectious Diseases, v. 23, p. 256-270, 2004. GROTTE, M.; YOUNGER, B. Sporotrichosis associated with sphagnum moss exposure. Archives of Pathology & Laboratory Medicine, v. 105, p. 50-51, 1981. 63 GUARRO, J.; GENÉ, J.; STCHIGEL, A. M. Developments in fungal taxonomy. Clinical Microbiology Reviews, v. 12, p. 454-500, 1999. GULLBERG, R. M.; QUINTANILLA, A.; LEVIN, M. L.; WILLIAMS, J.; PHAIR, J. P. Sporotrichosis: recurrent cutaneous, articular and central nervous system infection in a renal transplant recipient. Reviews of Infectious Disease, v. 9, p. 369-375, 1987. HAMILL, R. J. Amphotericin B formulations: A comparative review of efficacy and toxicity. Drugs, v. 73, p. 919-934, 2013. HAN, H. S.; KANO, R.; CHEN, C.; NOLI, C. Comparison of two in vitro antifungal sensitivity tests and monitoring during therapy of Sporothrix schenckii sensu stricto in Malaysian cats. Veterinary Dermatology, v. 28, p. 156-160, 2017. HEKTOEN, L.; PERKINS, M. D. Refractory subcutaneous abscess caused by Sporothrix schenckii. A new pathogenic fungus. The Journal of Experimental Medicine, v. 5, p. 77-91, 1899. HIRANO, M.; WATANABE, K.; MURAKAMI, M.; KANO, R.; YANAI, T.; YAMAZOE, K.; FUKATA, T.; KUDO, T. A case of feline sporotrichosis. The Journal of Veterinary Medical Science, v. 68, n. 3, p. 283-284, 2006. HOGAN, L. H.; KLEIN, B. S. Altered expression of surface alpha-1,3-glucan in genetically related strains of Blastomyces dermatitidis that differ in virulence. Infection and Immunity, v. 62, p. 3543-3546, 1994. HOGAN, L. H.; KLEIN, B. S.; LEVITZ, S. M. Virulence Factors of Medically Important Fungi. Clinical Microbiology Reviews, v. 9, n. 4, p. 469-488, 1996. HONSE, C. O.; RODRIGUES, A. M.; GREMIÃO, I. D. F.; PEREIRA, S. A.; SCHUBACH, T. M. P. Use of local hyperthermia to treat sporotrichosis in a cat. Veterinary Record, v. 166, n. 7, p. 208-209, 2010. HOOG, G. S.; GUARRO, J.; GENÉ, J.; FIGUERAS, M. J. Atlas of Clinical Fungi. 2ed. The Netherlands and Spain: Centraalbureau voor Schimmelcultures / Universitat Rovira i Virgili, 2001. 1126 p. HU, S.; CHUNG, W. H.; HUNG, S. I.; HO, H. C.; WANG, Z. W.; CHIEN, C. H.; LU, S. C.; KUO, T. T.; HONG, H. S. Detection of Sporothrix schenckii in clinical samples by nested PCR assay. Journal of Clinical Microbiology, v. 41, n. 4, p. 1414-1418, 2003. JOHNSON, E. M.; SZEKELY, A.; WARNOCK, D. W. In-vitro activity of voriconazole, itraconazole and amphotericin B against filamentous fungi. Journal of Antimicrobial Chemotherapy, v. 42, p. 741-745, 1998. KAN, V. L.; BENNETT, J. E. Efficacies of four antifungal agents in experimental murine sporotrichosis. Antimicrobial Agents and Chemotherapy, v. 32, n.11, p. 1619-1623, 1988. KANO, R.; MATSUOKA, A.; KASHIMI, M.; NAKAMURA, Y.; WATANABE, S.; MIZOGUCHI, M.; HASEGAWA, A. Detection of Sporothrix schenckii chitin synthase 1 (CHS1) gene in biopsy specimens from human patients with sporotrichosis. Journal of Dermatological Science, v. 33, p. 73,74, 2003. 64 KANO, R.; WATANABE, K.; MURAKAMI, M.; YANAI, T.; HASEGAWA, A. Molecular diagnosis of feline sporotrichosis. Veterinary Record, v. 156, p. 484-485, 2005. KAUFFMAN, C. A. Sporotrichosis. Clinical Infectious Diseases, v. 29, p. 231-237, 1999. KAUFFMAN, C. A.; BUSTAMANTE, B.; CHAPMAN, S. W.; PAPPAS, P. G. Clinical Practice Guidelines for the Management of Sporotrichosis: 2007 Update by Infectious Disease Society of America.Clinical Infectious Disease, v. 45, p. 1255-1265, 2007. KAUFFMAN, C. A.; PAPPAS, P. G.; MCKINSEY, D. S.; GREENFIELD, R. A.; PERFECT, J. R.; CLOUD, G. A.; THOMAS, C. J.; DISMUKES, W. E. Treatment of lymphocutaneous and visceral sporotrichosis with fluconazole. Clinical Infectious Diseases, v. 22, p. 46-50, 1996. KAZANAS, N. Foodborne Sporothrix schenckii: Infectivity for mice by intraperitoneal and intragastric inoculation with conidia. Mycopathologia, v. 95, p. 3-16, 1986. KLEIN, B. S.; TEBBETS, B. Dimorphism and virulence in fungi. Current Opinion in Microbiology, v. 10, n. 4, p. 314-319, 2007. KOTNIK, T. Drug efficacy of terbinafine hydrochloride (Lamisil®) during oral treatment of cats, experimentally infected with Microsporum canis. Zoonoses and Public Health, v. 49, n. 3, p. 120-122, 2002. KURTZMAN, C. P.; FELL, J. W.; BOEKHOUT, T.; ROBERT, V. Methods for Isolation, Phenotypic Characterization and Maintenance of Yeasts. In: KURTZMAN, C. P.; FELL, J. W.; BOEKHOUT, T. The Yeasts: A taxonomic study. 5ed. Amsterdam: Elsevier, 2011. p. 87-110. KWON-CHUNG, K. J.; POLACHECK, I.; POPKIN, T. J. Melanin-lacking mutants of Cryptococcus neoformans and their virulence for mice. Journal of Bacteriology, v. 150, p. 1414-1421, 1982. KWON-CHUNG, K.J. Comparison of isolates of Sporothrix schenckii obtained from fixed cutaneous lesions with isolates from other types of lesions. The Journal of Infectious Disease, v. 139, p. 424-431, 1979. LARSSON, C. E. Esorotricose. Brazilian Journal of Veterinary Research and Animal Science, v. 48, n. 3, p. 250-259, 2011. LASS-FLORL, C. Triazole antifungal agents in invasive fungal infections: a comparative review. Drugs, v. 71, n. 18, p. 2405-2419, 2011. LIMA, O. C.; BOUCHARA, J. P; RENIER, G.; MAROT-LEBLOND, A.; CHABASSE, D.; LOPES-BEZERRA, L. M. Immunofluorescence and flow cytometry analysis of fibronectin and laminin binding to Sporothrix schenckii yeast cells and conidia. Microbial Pathogenesis, v. 37, p. 131-140, 2004. LIU, G. Y; NIZET, V. Color me bad: microbial pigments as virulence factors. Trends in Microbiology, v. 17, n. 9, p. 406-413, 2009. LIU, T.; ZHANG, K.; ZHOU, X. Molecular identification of Sporothrix clinical isolates in China. Journal of Zhejiang University-Science B (Biomedicine & Biotechnology), v. 15, n. 1, p. 100-108, 2014. 65 LUTZ, A.; SPLENDORE, A. Sobre uma mycose observada em homens e ratos. Revista Médica de São Paulo, v. 21, p. 433-450, 1907. MACEDO, P. M.; LOPES-BEZERRA, L. M.; BERNARDES-ENGEMANN, A. R.; OROFINO-COSTA, R. New posology of potassium iodide for the treatment of cutaneous sporotrichosis: study of efficacy and safety in 102 patients. Journal of the European Academy of Dermatology and Venereology, v. 29, n. 4, p. 719-724, 2015. MACKINNON, J. E.; CONTI DÍAZ, I. A. The effect of temperature on sporotrichosis. Sabouraudia, v. 2, p. 1956-1959, 1962. MACKINNON, J. E.; CONTÍ-DIAS, I. A.; GEZUELE, E.; CILIVA, E.; LUZ, S. Isolation of Sporothrix schenckii from nature considerations on its pathogenicity and ecology. Sabouraudia, v. 7, p. 38-45, 1969. MAGAND, F.; PERROT, J. L.; CAMBAZARD, F.; RABERIN, M. H.; LABEILLE, B. Sporotrichose cutanée autochtone française. Annales de dermatologie et de vénéréologie, v. 136, p. 273-275, 2009. MAHMOUDI, S.; ZAINI, F.; KORDBACHEH, P.; SAFARA,M .; HEIDARI, M. Sporothrix schenckii complex in Iran: Molecular identification and antifungal susceptibility. Medical Mycology, v. 54, n. 6, p. 593-599, 2016. MALIK, R.; VOGELNEST, L.; O’BRIEN, C. R.; WHITE, J.; HAWKE, C.; WIGNEY, D. I.; MARTIN, P.; NORRIS, J. M. Infections and some other conditions affecting the skin and subcutis of the naso-ocular region of cats – Clinical experience 1987-2003. Journal of Feline Medicine & Surgery, v. 6, n. 6, p. 383-390, 2004. MARIMON, R.; CANO, J.; GENÉ, J.; SUTTON, D. A.; KAWASAKI, M.; GUARRO, J. Sporothrix brasiliensis, S. globosa and S. mexicana, three new Sporothrix species of clinica interest. Journal of Clinical Microbiology, v. 45, n. 10, p. 3198-3206, 2007. MARIMON, R.; GENÉ, J.; CANO, J.; GUARRO, J. Molecular phylogeny of Sporothrix schenckii. Journal of Clinical Microbiology, v. 44, n. 9, p. 3251-3256, 2006. MARIMON, R.; GENÉ, J.; CANO, J.; GUARRO, J. Sporothrix luriei: a rare fungus from clinical origin. Medical Mycology, v. 46, p. 621-625, 2008a. MARIMON, R.; SERENA, C.; GENÉ, J.; CANO, J.; GUARRO, J. In vitro antifungal susceptibilities of five species of Sporothrix. Antimicrobial Agents and Chemotherapy, v. 52, n. 2, 2008b. MAUDY, T. H.; VAN DER VEGTE, W. H. Ultrastructure of septa in Blastobotrys and Sporothrix. Antonie van Leeuwenhoek, v. 51, p. 121-128, 1985. MCGINNIS, M. R.; NORDOFF, N.; LI, R. K.; PASARELL, L.; WARNOCK, D. W. Sporothrix schenckii sensitivity to voriconazole, itraconazole and amphotericin B. Medical Mycology, v. 39, p. 369-371, 2001. MEDOFF, G.; KOBAYASHI, G. S.; PAINTER, A.; TRAVIS, S. Morphogenesis and pathogenicity of Histoplasma capsulatum. Infection and Immunity, v. 55, n. 6, p. 1355- 1358, 1987. 66 MEINERZ, A. R. M.; NASCENTE, P. S.; SCHUCH, L. F. D.; CLEFF, M. B.; SANTIN, R.; BRUM, C. S.; NOBRE, M. O.; MEIRELES, M. C. A.; MELLO, J. R. B. Suscetibilidade in vitro de isolados de Sporothrix schenckii frente à terbinafina e itraconazol. Revista da Sociedade Brasileira de Medicina Tropical, v. 40, n. 1, p. 60-62, 2007. MESA-ARANGO, A. C.; REYES-MONTES, M. R.; PÉREZ-MEJÍA, A.; NAVARROBARRANCO, H.; SOUZA, V.; ZÚÑIGA, G.; TORIELLO, C. Phenotyping and genotyping of Sporothrix schenckii isolates according to geographic origin and clinical form of sporotrichosis. Journal of Clinical Microbiology, v. 40, n. 8, p. 3004-3011, 2002. MEYER, E. M.; SUMMERBELL, R. C.; MOHARRAM, A. M.; HOOG, G. S.; VISMER, H. F.; WINGFIELD, M. J. Taxonomy and phylogeny of new wood and soil-inhabiting Sporothrix species in the Ophiostoma stenoceras-Sporothrix schenckii complex. Mycologia, v. 100, n. 4, p. 647-661, 2008. MEYER, W.; CASTAÑEDA, A.; JACKSON, S.; HUYNH, M.; CASTAÑEDA, E. Molecular typing of IberoAmerican Cryptococcus neoformans isolates. Emergent Infectious Diseases, v. 9, n. 2, p. 189-195, 2003. MILLER, S. D.; KEELING, J. H.; Ant sting sporotrichosis. Cutis, v. 69, p. 439-442, 2002. MINISTÉRIO DA SAÚDE. Portaria 1.271 de 06 de junho de 2014. Define a Lista Nacional de Notificação Compulsória de doenças, agravos e eventos de saúde pública nos serviços de saúde públicos e privados em todo o território nacional, nos termos do anexo, e dá outras providências. Disponível em: http://bvsms.saude.gov.br/bvs/saudelegis/gm/2014/prt1271_06_06_2014.html. Acesso em 28 fev. 2017. MIRANDA, L. H. M.; SANTIAGO, M. A.; SCHUBACH, T. M. P.; MORGADO, F. N.; PEREIRA, S. A.; OLIVEIRA, R. V. C.; CONCEIÇÃO-SILVA, F. Severe feline sporotrichosis associated with an increased population of CD8low cells and a decrease in CD4+ cells. Medical Mycology, v. 54, n. 1, p. 29-39, 2016. MIRANDA, L. H.; CONCEIÇÃO-SILVA, F.; QUINTELLA, L. P.; KURAIEM, B. P.; PEREIRA, S. A.; SCHUBACH, T. M. P. Feline sporotrichosis: histopathological profile of cutaneous lesions and their correlation with clinical presentation. Comparative Imunnology, Microbiology & Infectious Disease, v. 36, n. 4, p. 425-432, 2013. MIRANDA, L. H.; QUINTELLA, L. P.; SANTOS, I. B.; MENEZES, R. C.; FIGUEIREDO, F. B.; GREMIÃO, I. D. F.; OKAMOTO, T.; OLIVEIRA, R. V. C.; PEREIRA, S. A.; TORTELLY, R.; SCHUBACH, T. M. P. Histopathology of canine sporotrichosis: a morphological study of 86 cases from Rio de Janeiro (2001-2007). Mycopathologia, v. 168, n. 2, p. 79-87, 2009. MONTENEGRO, H.; RODRIGUES, A. M.; DIAS, M. A. G.; SILVA, E. A.; BERNARDI, F.; CAMARGO, Z. P. Feline sporotrichosis due to Sporothrix brasiliensis: an emerging animal infection in São Paulo, Brazil. BMC Veterinary Research, v. 10, 269, 2014. MORRIS-JONES, R.; YOUNGCHIM, S.; GOMES, B. L.; AISEN, P.; HAY, R. J.; NOSANCHUK, J. D.; CASADEVALL, A.; HAMILTON, A. J. Synthesis of melanin-like pigments by Sporothrix schenckii in vitro and during mammalian infection. Infection and Immunity, v.71, n. 7, p. 4026-4033, 2003. 67 NORIEGA, C. T. R. R.; GUARAY, R. R.; SABANERO, G.; BASURTO, R. T.; LÓPEZ, M. S. Sporothrix schenckii: culturas em diferentes suelos. Revista Latinoamericana de Micologia, v. 35, p. 191-194, 1993. O’DONNEL, K.; NIRENBERG, H. I.; AOKI, T.; CIGELNIK, E. A multigene phylogeny of the Gibberella fujikuroi species complex: Detection of additional phylogenetically distinct species. Mycoscience, v. 41, p. 61-78, 2000. O’REILLY, L. C.; ALTMAN, S. A. Macrorestriction analasys of clinical and environmental isolates of Sporothrix schenckii. Journal of Clinical Microbiology, v. 44, n. 7, p. 2547-2552, 2006. OLIVEIRA, D. C.; LORETO, E. S.; MARIO, D. A. N.; LOPES, P. G. M.; NEVES, L. V.; ROCHA, M. P.; SANTÚRIO, J. M.; ALVES, S. H. Antifungal susceptibilities of Sporothrix albicans, S. brasiliensis and S. luriei of the S. schenckii complex identified in Brazil. Journal of Clinical Microbiology, v. 48, n. 8, p. 3047-3049, 2011. OLIVEIRA, M. M. E.; ALMEIDA-PAES, R.; MUNIZ, M. M.; GUTIERREZ-GALHARDO, M. C.; ZANCOPÉ-OLIVEIRA, R. M. Phenotypic and molecular identification of Sporothrix isolates from an epidemic area of sporotrichosis in Brazil. Mycopathologia, v. 172, p. 257- 267, 2011. OLIVEIRA, M. M. E.; ALMEIDA-PAES, R.; GUTIERREZ-GALHARDO, M. C.; ZANCOPÉ-OLIVEIRA, R. M. Molecular identification of the Sporothrix schenckii complex. Revista Iberoamericana de Micologia, v. 31, n.1, p. 2-6, 2014. OLIVEIRA, M. M. E.; ALMEIDA-PAES, R.; MUNIZ, M. M.; BARROS, M. B. L.; GUTIERREZ-GALHARDO, M. C.; ZANCOPÉ-OLIVEIRA, R. M. Sporotrichosis caused by Sporothrix globosa in Rio de Janeiro, Brazil: Case report. Mycopathologia, v. 169, p. 359- 363, 2010. OLIVEIRA, M. M. E.; FRANCO-DUARTE, R.; ROMEO, O.; PAIS, C.; CRISEO, G.; SAMPAIO, P.; ZANCOPÉ-OLIVEIRA, R. M.; POEGGELER, S. Evaluation of T3B fingerprinting for identification of clinical and environmental Sporothrix species. FEMS Microbiology Letters, v. 362, n. 6, fnv027, 2015. OLIVEIRA, M. M. E.; SAMPAIO, P.; ALMEIDA-PAES, R.; PAIS, C.; GUTIERREZGALHARDO, M. C.; ZANCOPÉ-OLIVEIRA, R. M. Rapid identification of Sporothrix species by T3B fingerprinting. Journal of Clinical Microbiology, v. 50, n. 6, p. 2159-2162, 2012. PAPPAS, P. G.; TELEZ, I.; DEEP, A. E.; NOLASCO, D.; HOLGADO, W.; BUSTAMANTE, B. Sporotrichosis in Peru: Description of an area of hyperendemicity. Clinical Infectious Diseases, v. 30, p. 65-70, 2000. PEREIRA, S. A.; GREMIÃO, I. D. F.; KITADA, A. A. B.; BOECHAT, J. S.; VIANA, P. G.; SCHUBACH, T. M. P. The epidemiological scenario of feline sporotrichosis in Rio de Janeiro, State of Rio de Janeiro, Brazil. Revista da Sociedade Brasileira de Medicina Tropical, v. 47, n. 3, p. 292-293, 2014. PEREIRA, S. A.; MENEZES, R. C.; GREMIÃO, I. D. F., SILVA, J. N.; HONSE, C. O.; FIGUEIREDO, F. B.; SILVA, D. T.; KITADA, A. A. B.; REIS, E. G.; SCHUBACH, T. M. 68 P. Sensitivity of cytopathological examination in the diagnosis of feline sporotrichosis. Journal of Feline Medicine & Surgery, v. 13, p. 220-223, 2011. PEREIRA, S. A.; SCHUBACH, T. M. P.; GREMIÃO, I. D. F.; SILVA, D. T.; FIGUEIREDO, F. B.; ASSIS, N. V.; PASSOS, S. R. L. Aspectos terapêuticos da esporotricose felina. Acta Scientiae Veterinariae, v. 37, n. 4, p. 311-321, 2009. PEREIRA, S. A.; PASSOS, S. R. L.; SILVA, J. N.; GREMIÃO, I. D. F.; FIGUEIREDO, F. B.; TEIXEIRA, J. L.; MONTEIRO, P. C. F.; SCHUBACH, T. M. P. Response to azolic antifungal agents for treating feline sporotrichosis. Veterinary Records, v. 166, n. 10, p. 290- 294, 2010. PETERSEN, R. H.; HUGHES, K. W. Species and speciation in mushrooms: development of a species concept poses difficulties. Bioscience, v. 49, p. 440-452, 1999. PEYTON, L. R.; GALLAGHER, S.; HASHEMZADEH, M. Triazole antifungals: A review.Drugs of Today, v. 51, n. 12, p. 705-718, 2015. PLUSS, J. L. D. O.; OPAL, S. M. M. D. Pulmonary sporotrichosis: review of treatment and outcome. Medicine (Baltimore), v. 65, p. 143-153, 1986. POWELL, K. E.; TAYLOR, A.; PHILLIPS, B. J.; BLAKEY, D. L.; CAMPBELL, G. D.; KAUFMAN, L.; KAPLAN, W. Cutaneous sporotrichosis in forestry workers. Epidemic due to contaminated Sphagnum moss. Journal of American Medical Association, v. 240, n. 3, p. 232-235, 1978. QUEIROZ-TELLES, F.; NUCCI, M.; COLOMBO, A. L.; TOBÓN, A.; RESTREPO, A. Mycoses of implantation in Latin America: an overview of epidemiology, clinical manifestation, diagnosis and treatment. Medical Mycology, v. 49, n. 3, p. 225-236, 2011. RAPPLEYE, C. A.; ENGLE, J. T.; GOLDMAN, M. E. RNA interference in Histoplasma capsulatum demonstrates a role for alpha-(1,3)-glucan in virulence. Molecular Microbiology, v. 53, p. 153-165, 2004. READ, S. I.; SPERLING, L. C. Feline sporotrichosis. Transmission to man. Archives of Dermatology v., 118, p. 429-431, 1982. REIS, E. G.; GREMIÃO, I. D. F.; KITADA, A. A. B.; ROCHA, R. F. D. B.; CASTRO, V. S. P.; BARROS, M. B. L.; MENEZES, R. C.; PEREIRA, S. A.; SCHUBACH, T. M. P. Potassium iodine capsule treatment of feline sporotrichosis. Journal of Feline Medicine and Surgery, v. 14, n. 6, 399-404, 2012. REIS, E. G.; SCHUBACH, T. M. P.; PEREIRA, S. A.; SILVA, J. N.; CARVALHO, B. W.; QUINTANA, M. S. B.; GREMIÃO, I. D. F. Association of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective study. Medical Mycology, v. 54, n. 7, p. 684-690, 2016. REIS, R. S.; ALMEIDA-PAES, R.; MUNIZ, M. M.; TAVARES, P. M. S.; MONTEIRO, P. C. F.; SCHUBACH, T. M. P.; GUTIERREZ-GALHARDO, M. C.; ZANCOPÉ-OLIVEIRA, R. M. Molecular characterization of Sporothrix schenckii isolates from humans and cats involved in the sporotrichosis epidemic in Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, v. 104, n. 5, p. 769-774, 2009. 69 RIO DE JANEIRO (Estado). Resolução nº 647, de 12 de junho de 2013. Redefine a relação de doenças e agravos de notificação compulsória no âmbito do Estado do Rio de Janeiro. Diário Oficial, RJ, 16 jul. 2013. ROBERTO, T. N.; RODRIGUES, A. M.; HAHN, R. C.; CAMARGO, Z. P. Identifying Paracoccidiodes phylogenetic species by PCR-RFLP of the alpha-tubulin gene. Medical Mycology, v. 54, n. 3, p. 240-247, 2015. ROCHETTE, F.; ENGELEN, M.; VANDEN BOSSCHE, H. Antifungal agents of use in animal health – practical applications. Journal of Veterinary Pharmacology and Therapeutics, v. 26, p. 31-53, 2003. RODRIGUES, A. M.; CRUZ-CHOAPPA, R.; FERNANDES, G. F.; HOOG, G. S.; CAMARGO, Z. P. Sporothrix chilensis sp. nov. (Ascomycota: Ophiostomatales) a soil-borne agent of human sporotrichosis with mild-pathogenic potential to mammals. Fungal Biology, v. 120, p. 246-264, 2016a. RODRIGUES, A. M.; HOOG, G. S.; CAMARGO, Z. P. Genotyping species of the Sporothrix schenckii complex by PCR-RFLP of calmodulin. Diagnostic Microbiology and Infectious Disease, v. 78, p. 383-387, 2014a. RODRIGUES, A. M.; HOOG, G. S.; CAMARGO, Z. P. Molecular diagnosis of pathogenic Sporothrix species. PLOS Neglected Tropical Diseases, v. 9, n. 12, e0004190, 2015. RODRIGUES, A. M.; HOOG, G. S.; CAMARGO, Z. P. Sporothrix species causing outbreaks in animals and humans driven by anima-animal transmission. PLOS Pathogen, v. 12, n. 7, e1005638, 2016b. RODRIGUES, A. M.; HOOG, G. S.; PIRES, D. C.; BRILHANTE, R. S. N.; SIDRIM, J. J. C.; GADELHA, M. F.; COLOMBO, A. L.; CAMARGO, Z. P. Genetic diversity and antifungal susceptibility profiles in causative agents of sporotrichosis. BMC Infectious Diseases, v. 14, 219, 2014b. RODRIGUES, A. M.; HOOG, G. S.; ZHANG, Y.; CAMARGO, Z. P. Emerging sporotrichosis is driven by clonal and recombinant Sporothrix species. Emerging Microbes and Infection, v. 3, e32, 2014c. RODRIGUES, A. M.; HOOG, S.; CAMARGO, Z. P. Emergence of pathogenicity in the Sporothrix schenckii complex. Medical Mycology, v. 51, n. 4, p. 405-412, 2013a. RODRIGUES, A. M.; TEIXEIRA, M. M.; HOOG, G. S.; SCHUBACH, T. M. P.; PEREIRA, S. A.; FERNANDES, G. F.; BEZERRA, L. M. L.; FELIPE, M. S.; CAMARGO, Z. P. Phylogenetic analysis reveals a high prevalence of Sporothrix brasiliensis in feline sporotrichosis outbreaks. PLOS Neglected Tropical Diseases, v. 7, n. 6, e2281, 2013b. ROMEO, O.; SCORDINO, F.; CRISEO, G. New insight into molecular phylogeny and epidemiology of Sporothrix schenckii species complex based on calmodulin-encoding gene analysis of Italian isolates. Mycopathologia, v. 172, n. 3, p. 179-186, 2011. 70 SANCHOTENE, K. O.; MADRID, I. M.; KLAFKE, G. B.; BERGAMASHI, M.; TERRA, P. P. D.; RODRIGUES, A. M.; CAMARGO, Z. P.; XAVIER, M. O. Sporothrix brasiliensis outbreaks and the rapid emergence of feline sporotrichosis. Mycoses, v. 58, p. 652-658, 2015. SANDHU, G. S.; KLINE, B. C.; STOCKMAN, L.; ROBERTS, G. D. Molecular probes for diagnosis of fungal infections. Journal of Clinical Microbiology, v. 33, n. 11, p. 2913-2919, 1995. SCHENCK, B. R. On refractory subcutaneous abscesses caused by a fungus possibly related to sporothrichia. Bulletin of the Johns Hopkins Hospital, v. 9, p. 286-290, 1898. SCHUBACH, T. M. P.; SCHUBACH, A. O. Esporotricose em gatos e cães – revisão. Clínica Veterinária, v. 29, p. 21-24, 2000. SCHUBACH, T. M. P.; SCHUBACH, A. O.; CUZZI-MAYA, T.; OKAMOTO, T.; REIS, R. S.; MONTEIRO, P. C.; GUTIERREZ-GALHARDO, M. C.; WANKE, B. Pathology of sporotrichosis in 10 cats in Rio de Janeiro. Veterinary Records, v. 152, n. 6, p. 172-175, 2003. SCHUBACH, T. M.; MENEZES, R. C.; WANKE, B. Sporotrichosis. In: GREENE, C.E. (Ed.) Infectious diseases of the dog and cat. 4ed. Missouri: Elsevier, 2012. p. 645-650. SCHUBACH, T. M.; SCHBACH, A.; OKAMOTO, T.; BARROS, M. B. L.; FIGUEIREDO, F. B.; CUZZI, T.; FIALHO-MONTEIRO, P. C.; REIS, R. S.; PEREZ, M . A; WANKE, B. Evaluation of an epidemic of sporotrichosis in cats: 347 cases (1998-2001). Journal of the American Veterinary Medical Association, v. 224, n. 10, p. 1623-1629, 2004. SCHUBACH, T. M.; SCHUBACH, A.; OKAMOTO, T.; BARROS, M. B. L.; FIGUEIREDO, F. B.; CUZZI-MAYA, T.; PEREIRA, S. A.; SANTOS, I. B.; ALMEIDAPAES, R.; PAES-LEME, L. R.; WANKE, B. Canine sporotrichosis in Rio de Janeiro, Brazil: clinical presentation, laboratory diagnosis and therapeutic response in 44 cases (1998-2003). Medical Mycology, v. 44, n. 1, p. 87-92, 2006. SHEENAN, D. J.; HITCHCOCK, C. A.; SIBLEY, C. M. Current and emerging azole antifungal agents. Clinical Microbiology Reviews, v. 12, n. 1, p. 40-79, 1999. SILVA, J. N.; PASSOS, S. R. L.; MENEZES, R. C.; GREMIÃO, I, D. F.; SCHUBACH, T. M. P.; OLIVEIRA, J. C.; FIGUEIREDO, A. B. F.; PEREIRA, S. A. Diagnostic accuracy assessment of cytopathological examination of feline sporotrichosis. Medical Mycology, v. 53, p. 1-5, 2015. SILVA, M. B. T.; COSTA, M. M. M.; TORRE, C. C. S.; GUTIERREZ-GALHARDO, M. C.; VALLE, A. C. F.; MAGALHÃES, M. A. F. M.; SABROZA, P. C.; OLIVEIRA, R. M. Esporotricose urbana: epidemia negligenciada no Rio de Janeiro, Brasil. Cadernos de Saúde Pública, v. 28, n. 10, p. 1867-1880, 2012. SINGER, J. I.; MUNCIE, J. E. Sporotrichosis: etiologic considerations and report of additional cases from New York. New York State Journal of Medicine, v. 52, p. 2147-2153, 1952. SONG, Y.; LI, S. S.; ZHONG, S. X.; LIU, Y. Y.; YAO, L.; HUO, S. S. Report of 457 sporotrichosis cases from Jilin province, northeast China, a serious endemic region. Journal of the European Academy of Dermatology and Venereology, v. 27, p. 313-318, 2013. 71 SOUZA, C. P.; LUCAS, R.; RAMADINHA, R. H. R.; PIRES, T. B. C. P. Cryosurgery in association with itraconazole for the treatment of feline sporotrichosis. Journal of Feline Medicine and Surgery, v. 18, n. 2, p. 137-143, 2015 SOUZA, L. L.; NASCENTE, P. S.; NOBRE, M. O.; MEINERZ, A. R. M.; MEIRELES, M. C. A. Isolation of Sporothrix schenckii from the nail of healthy cats. Brazilian Journal of Microbiology, v. 37, n. 3, p. 372-374, 2006. STERLING, J. B.; HEYMANN, W. R. Potassium iodide in dermatology: a 19th century drug for 21st century uses, adverse effects, and contraindications. Journal of the American Academy of Dermatology, v. 43, p. 691-697, 2000. STOPIGLIA, C. D. O.; MAGAGNIN, C. M.; CASTRILLÓN, M. R.; MENDES, S. D. C.; HEIDRICH, D.; VALENTE, P.; SCROFERNEKER, M. L. Antifungal susceptibilities and identification of species of the Sporothrix schenckii complex isolated in Brazil. Medical Mycology, v. 52, p. 56-64, 2014. STOPIGLIA, C. D. O.; MARCHESE, D. P; HEIDRICH, D.; SORRENTINO, J. M.; VIEIRA, F. J.; SCROFERNEKER, M. L. Comparison between two culture media for in vitro evaluation of antifungal susceptibility of the Sporothrix schenckii complex. Anais Brasileiros de Dermatologia, v. 87, n. 4, p. 561-565, 2012. TAKEDA, Y.; KAWASAKI, M.; ISHIZAKI, H. Phylogeny and molecular epidemiology of Sporothrix schenckii in Japan. Mycopathologia, v. 116, n. 1, p. 9-14, 1991. TRILLES, L.; FERNÁNDEZ-TORRES, B.; LAZÉRA, M. S.; WANKE, B.; SCHUBACH, A. O.; ALMEIDA-PAES, R.; INZA, I.; GUARRO, J. In vitro antifungal susceptibilities of Sporothrix schenckii in two growth phases. Antimicrobial Agents and Chemotherapy, v. 49, p. 3952-3954, 2005. VANDER BOSSCHE, H.; ENGELEN, M.; ROCHETTE, F. Antifungal agents of use in animal health – chemical, biochemical and pharmacological aspects. Journal of Veterinary Pharmacology and Therapeutics, v. 26, p. 5-29, 2003. WANG, Y.; AISEN, P.; CASADEVALL, A. Cryptococcus neoformans melanin and virulence mechanism of action. Infection and Immunity, v. 63, n. 8, p. 3131-3136, 1995. WATANABE, M.; HAYAMA, K.; FUJITA, H.; YAGOSHI, M.; YARITA, K.; KAMEI, K.; TERUI, T. A case of sporotrichosis caused by Sporothrix globosa in Japan. Annals of Dermatology, v. 28, n. 2, p. 251-252, 2016. WILLEMS, L.; VAN DER GEEST, R.; DE BEULE, K. Itraconazole oral solution and itravenous formulations: a review of pharmacokinetics and pharmacodynamics. Journal of Clinical Pharmacy and Therapeutics, v. 26, n. 3, p. 159-169, 2001. YU, X; WAN, Z.; ZHANG, Z.; LI, F.; LI, R.; LIU, X. Phenotypic and molecular identification of Sporothrix isolates of clinical origin in Northeast China. Mycopathologia, v. 176, p. 67-74, 2013. ZHAO, M.; ZHOU, X.; LIU, T.; YANG, Z. Morphological and physiological comparison of taxa comprising the Sporothrix schenckii complex. Journal of Zhejiang University - Science B, v. 16, n. 11, p. 940-947, 2015. 72 ZHOU, X.; RODRIGUES, A. M.; FENG, P.; HOOG, G. S. Global ITS diversity in the Sporothrix schenckii complex. Fungal Diversity, v. 66, p. 153-165, 2014.por
dc.subject.cnpqMedicina Veterináriapor
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/6106/2017%20-%20Daniel%20Paiva%20Barros%20de%20Abreu.pdf.jpg*
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/20922/2017%20-%20Daniel%20Paiva%20Barros%20de%20Abreu.pdf.jpg*
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/27291/2017%20-%20Daniel%20Paiva%20Barros%20de%20Abreu.pdf.jpg*
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/33706/2017%20-%20Daniel%20Paiva%20Barros%20de%20Abreu.pdf.jpg*
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/40056/2017%20-%20Daniel%20Paiva%20Barros%20de%20Abreu.pdf.jpg*
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/46476/2017%20-%20Daniel%20Paiva%20Barros%20de%20Abreu.pdf.jpg*
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/52798/2017%20-%20Daniel%20Paiva%20Barros%20de%20Abreu.pdf.jpg*
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/59292/2017%20-%20Daniel%20Paiva%20Barros%20de%20Abreu.pdf.jpg*
dc.originais.urihttps://tede.ufrrj.br/jspui/handle/jspui/2031
dc.originais.provenanceSubmitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2017-09-13T12:31:48Z No. of bitstreams: 1 2017 - Daniel Paiva Barros de Abreu.pdf: 1307092 bytes, checksum: b384d4db2cb316d3f640b111bc8efba4 (MD5)eng
dc.originais.provenanceMade available in DSpace on 2017-09-13T12:31:48Z (GMT). No. of bitstreams: 1 2017 - Daniel Paiva Barros de Abreu.pdf: 1307092 bytes, checksum: b384d4db2cb316d3f640b111bc8efba4 (MD5) Previous issue date: 2017-02-20eng
Appears in Collections:Mestrado em Medicina Veterinária (Patologia e Ciências Clínicas)

Se for cadastrado no RIMA, poderá receber informações por email.
Se ainda não tem uma conta, cadastre-se aqui!

Files in This Item:
File Description SizeFormat 
2017 - Daniel Paiva Barros de Abreu.pdfDaniel Paiva Barros de Abreu1.28 MBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.