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dc.contributor.authorMohammad, Siraj Salman
dc.date.accessioned2023-12-22T01:45:29Z-
dc.date.available2023-12-22T01:45:29Z-
dc.date.issued2019-08-02
dc.identifier.citationMOHAMMAD, Siraj Salman. Separação e purificação de compostos de antocianina a partir do resíduo da fermentação de casca da uva variedade Alicante Bouschet utilizando resinas macroporosas. 2019. Dissertação (Mestrado em Ciência e Tecnologia de Alimentos) - Instituto de Tecnologia, Departamento de Tecnologia de Alimentos, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2019.por
dc.identifier.urihttps://rima.ufrrj.br/jspui/handle/20.500.14407/11005-
dc.description.abstractAs uvas são uma das culturas frutíferas mais comumente produzidas no mundo. Consequentemente, a indústria da uva produz grandes quantidades de bagaço, que é uma fonte rica em polifenóis que promovem a saúde, como proantocianidinas, flavonas e flavan-3-ols. Neste contexto, existem muitos tipos de adsorventes disponíveis, como as resinas macroporosas (MARs), as quais são relatadas como sendo mais eficiente para a recuperação de polifenóis devido às suas características e por apresentarem baixo custo, alta capacidade de recuperação e longo prazo de validade. Portanto, neste estudo, a matéria prima utilizada foi o resíduo da fermentação de casca de uva Alicante Bouschet da produção de vinho tinto, (1 g) de bagaço de uva seco foi pesado e extraído com 12,5 mL de 50% de água e 50% de etanol, o resíduo foi extraído novamente pelo mesmo volume de solução, as características de adsorção desorção de antocianinas de resíduo da fermentação de casca da uva Alicante Bouschet (RFCU) em seis tipos de resinas macroporosas (XAD 2, XAD 4, XAD 7HP, XAD 8, XAD 11 e XAD 16) foram investigadas. Nos testes de adsorção estáticos, XAD 7HP e DAX 8 apresentaram os melhores desempenhos para a antocianina total (AT). Os estudos das isotermas indicaram que o mecanismo de adsorção foi melhor explicado pelo modelo de isoterma de Langmuir. Por sua vez, as cinéticas de adsorção foram melhor explicados pelo modelo de pseudo-segunda ordem. O processo de adsorção utilizando as resinas XAD 7HP e DAX 8 foram isotérmicos nas temperaturas avaliadas (30 °C, 40 °C e 50 °C). Os extratos purificados apresentaram alta capacidade antioxidante acessadas pelos métodos FRAP e DPPH. Em relação à análise por cromatografia líquida de alta eficiência (CLAE), Peonidina, Peonidina-3-glicosídeo acilada, malvidina acilada e malvidina-3-glicosídeo foram os quatro principais compostos antociânicos tanto no extrato inicial quanto no purificado. No geral, as resinas macroporosas demonstraram potencial como alternativa na purificação e separação de antocianinas de resíduo de vinícolas, ao uso solventes orgânicos.por
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpor
dc.formatapplication/pdf*
dc.languageporpor
dc.publisherUniversidade Federal Rural do Rio de Janeiropor
dc.rightsAcesso Abertopor
dc.subjectpurificaçãopor
dc.subjectpolifenóispor
dc.subjectextraçãopor
dc.subjectantioxidantepor
dc.subjectpurificationeng
dc.subjectpolyphenoleng
dc.subjectextractioneng
dc.subjectantioxidanteng
dc.titleSeparação e purificação de compostos de antocianina a partir do resíduo da fermentação de casca da uva variedade Alicante Bouschet utilizando resinas macroporosaspor
dc.title.alternativeSeparation and purification of anthocyanin compounds from grape wine pele pomace (Alicante Bouschet) using macroporous resineng
dc.typeDissertaçãopor
dc.description.abstractOtherGrapes are one of the most commonly produced fruit crops in the world. Consequently, the grape industry produces large quantities of grape pomace which is a rich source of health promoting polyphenols such as proanthocyanidins, flavones and flavan-3-ols, in this context, there are many types of adsorbents available, but macroporous resins are reported to be the most efficient for polyphenol recovery because of its characteristics like low cost, high recuperative capacity and long term-validity. Therefore; in this study, the raw material used was the residue from grape fermentation of Alicante Bouschet from the production of red wine, (1 g) of dry GP was weighed and extracted with 12.5 mL of 50% water and 50% ethanol, the residue was extracted again by the same volume of solution, the adsorption/desorption characteristics of grape wine peel pomace (GWPP) anthocyanins on six types of macroporous resins (XAD 2, XAD 4, XAD 7HP, XAD 8, XAD 11 and XAD 16 were investigated. On basis of static adsorption test, XAD-7HP and DAX 8 showed higher adsorption/desorption capacities. The adsorption mechanism indicated that the process was better explained by pseudo-first-order kinetics and the Langmuir isotherm model. Adsorption isotherm tests showed that the adsorption process was exothermic on XAD 7HP and DAX 8 when performed at 30° C, 40 °C and 50 °C. The results of antioxidant tests indicate that purified anthocyanin extract showed high antioxidant capacity in the both methods of FRAP and DPPH Regarding to high-performance liquid chromatography analysis, acylated Peonidin, Peonidin-3-glucoside, acylated malvidin and malvidine-3-glucoside are the four main anthocyanin compounds in the initial and purified extract of GWPP. Overall, macroporous resins can be an effective tool to purificate anthocyanin instead of using organic solvents and supply pharmaceutical and food industry with safe and cheap process.eng
dc.contributor.advisor1Barbosa Junior, José Lucena
dc.contributor.advisor1IDCPF: 043.024.047-36por
dc.contributor.referee1Barbosa Junior, José Lucena
dc.contributor.referee2Vicente, Juarez
dc.contributor.referee3Rodrigues, Nathália da Rocha
dc.creator.IDCPF: 064.339.277-77por
dc.publisher.countryBrasilpor
dc.publisher.departmentInstituto de Tecnologiapor
dc.publisher.initialsUFRRJpor
dc.publisher.programPrograma de Pós-Graduação em Ciência e Tecnologia de Alimentospor
dc.relation.references---CAPITULO I --- ABYARI, M.; HEIDARI, R.; JAMEI, R. The effect of heating, UV irradiation and pH on stability of Siahe Sardasht Grape anthocyanin–copigment complex. Journal of Biological Science, v. 6, n. 4, p. 638-645, 2006. AL-FARTOSY, A. J.; ABDULWAHID, A. A. Antioxidant activity of anthocyanins extracted from Iraqi Iresine herbstii L. flowers after drying and freezing. American Journal of Analytical Chemistry, v.6, n. 05, p. 382, 2015. ANDRIAMBELOSON, E. et al. Nitric oxide production and endothelium‐dependent vasorelaxation induced by wine polyphenols in rat aorta. British journal of pharmacology, v. 120, n. 6, p. 1053-1058, 1997. ISSN 0007-1188. ANTAL, D.-S.; GARBAN, G.; GARBAN, Z. The anthocyans: biologically-active substances of food and pharmaceutic interest. Annals of the University Dunarea de Jos of Galati, Fascicle VI: Food Technology, p. 106-115, 2003. ANWAR, S. et al. Berry anthocyanins reduce proliferation of human colorectal carcinoma cells by inducing caspase-3 activation and p21 upregulation. Molecular medicine reports, v. 14, n. 2, p. 1397-1403, 2016. ISSN 1791-2997. AQIL, F. et al. Antioxidant and antiproliferative activities of anthocyanin/ellagitannin-enriched extracts from Syzygium cumini L.(Jamun, the Indian Blackberry). Nutrition and cancer, v. 64, n. 3, p. 428-438, 2012. ISSN 0163-5581. AZAR, M.; VERETTE, E.; BRUN, S. Identification of some phenolic compounds in bilberry juice Vaccinium myrtillus. J. Food Sci., 52:1255–1257., 1987. BISHAYEE, A. et al. Anthocyanin-rich black currant extract suppresses the growth of human hepatocellular carcinoma cells. Natural product communications, v. 5, n. 10, p. 1613-1618, 2010. ISSN 1934-578X. BORKOWSKI, T. et al. The effect of 3-O-β-glucosylation on structural transformations of anthocyanidins. Food research international, v. 38, n. 8-9, p. 1031-1037, 2005. ISSN 0963-9969. BOULTON, R. The copigmentation of anthocyanins and its role in the color of red wine: a critical review. American journal of enology and viticulture, v. 52, n. 2, p. 67-87, 2001. ISSN 0002-9254. BRIDLE, P.; TIMBERLAKE, C. Anthocyanins as natural food colours—selected aspects. Food chemistry, v. 58, n. 1-2, p. 103-109, 1997. ISSN 0308-8146. BROUILLARD, R. Chemical structure of anthocyanins. Academic Press: New York, 1982. BROUILLARD, R.; DELAPORTE, B. Chemistry of anthocyanin pigments. 2. Kinetic and thermodynamic study of proton transfer, hydration, and tautomeric reactions of malvidin 3-glucoside. Journal of the American Chemical Society, v. 99, n. 26, p. 8461-8468, 1977. ISSN 0002-7863. BUNEA, A. et al. Anthocyanin determination in blueberry extracts from various cultivars and their antiproliferative and apoptotic properties in B16-F10 metastatic murine melanoma cells. Phytochemistry, v. 95, p. 436-444, 2013. ISSN 0031-9422. CACACE, J.; MAZZA, G. Mass transfer process during extraction of phenolic compounds from milled berries. Journal of Food Engineering, v. 59, n. 4, p. 379-389, 2003. ISSN 0260-8774. CANTOS, E.; ESPIN, J. C.; TOMÁS-BARBERÁN, F. A. Effect of wounding on phenolic enzymes in six minimally processed lettuce cultivars upon storage. J. Agric. Food Chem., 49:322–330, 2001. CASTANEDA-OVANDO, A. et al. Chemical studies of anthocyanins: A review. Food chemistry, v. 113, n. 4, p. 859-871, 2009. ISSN 0308-8146. CHANDRA, A.; RANA, J.; LI, Y. Separation, identification, quanatitation, and method validation of anthocyanins in botanical supplement raw materials by HPLC and HPLC-MS. J. Agric. Food Chem., 49:3515–3521, 2001. CHEMAT, S. et al. Microwave-assisted extraction kinetics of terpenes from caraway seeds. Chemical Engineering and Processing: Process Intensification, v. 44, n. 12, p. 1320-1326, 2005. ISSN 0255-2701. CHEMINAT, A.; BROUILLARD, R. PMR investigation of 3-O-(β-D-glucosyl) malvidin structural transformations in aqueous solutions. Tetrahedron letters, v. 27, n. 37, p. 4457-4460, 1986. ISSN 0040-4039. CHEN, L.-J.; HRAZDINA, G. Structural aspects of anthocyanin-flavonoid complex formation and its role in plant color. Phytochemistry, v. 20, n. 2, p. 297-303, 1981/01/01/ 1981. ISSN 0031-9422. Available at: < http://www.sciencedirect.com/science/article/pii/0031942281851114 >. CHEN, L. et al. Dynamic microwave-assisted extraction of flavonoids from Herba Epimedii. Separation and Purification Technology, v. 59, n. 1, p. 50-57, 2008. ISSN 1383-5866. CLIFFORD, M. N. Anthocyanins–nature, occurrence and dietary burden. Journal of the Science of Food and Agriculture, v. 80, n. 7, p. 1063-1072, 2000. ISSN 0022-5142. COOK, N. C.; SAMMAN, S. Flavonoids-chemistry, metabolism, cardioprotective effects, and dietary sources. Nutr. Biochem., 7:66–76., 1996. COSTANTINO, L. et al. Activity of polyphenolic crude extracts as scavangers of superoxide radicals and inhibitors of xanthine oxidase. Planta medica, v. 58, n. 04, p. 342-344, 1992. ISSN 0032-0943. DA COSTA, C. T. et al. Separation of blackcurrant anthocyanins by capillary zone electrophoresis. Journal of Chromatography A, v. 799, n. 1-2, p. 321-327, 1998. ISSN 0021-9673. DA SILVA, D. F. et al. Effects of blackberries (Rupus sp.; cv. Xavante) processing on its physicochemical properties, phenolic contents and antioxidant activity. Journal of food science and technology, v. 55, n. 11, p. 4642-4649, 2018. ISSN 0022-1155. DAI, J.; MUMPER, R. J. Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules, v. 15, n. 10, p. 7313-7352, 2010. DEFURIA, J. et al. Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae. The Journal of nutrition, v. 139, n. 8, p. 1510-1516, 2009. ISSN 0022-3166. DEVASAGAYAM, T. et al. Free radicals and antioxidants in human health: current status and future prospects. Japi, v. 52, n. 794804, p. 4, 2004. DEVI, P. S.; KUMAR, M. S.; DAS, S. M. Evaluation of antiproliferative activity of red sorghum bran anthocyanin on a human breast cancer cell line (mcf-7). International journal of breast cancer, v. 2011, 2011. DONNER, H.; GAO, L.; MAZZA, G. Separation and characterization of simple and malonylated anthocyanins in red onions, Allium cepa L. Food Research International, v. 30, n. 8, p. 637-643, 1997. ISSN 0963-9969. EHLENFELDT, M. K.; PRIOR, R. L. Oxygen radical absorbance capacity (ORAC) and phenolic and anthocyanin concentrations in fruit and leaf tissues of highbush blueberry. Journal of Agricultural and Food Chemistry, v. 49, n. 5, p. 2222-2227, 2001. ISSN 0021-8561. FAN-CHIANG, H.-J. Anthocyanin pigment, nonvolatile acid and sugar composition of blackberries. 1999. FAN, G. et al. Optimizing conditions for anthocyanins extraction from purple sweet potato using response surface methodology (RSM). LWT-Food Science and Technology, v. 41, n. 1, p. 155-160, 2008. ISSN 0023-6438. FILIPIAK, K. et al. Dietary gallic acid and anthocyanin cytotoxicity on human fibrosarcoma HT1080 cells. A study on the mode of action. Food & function, v. 5, n. 2, p. 381-389, 2014. FIMOGNARI, C. et al. Induction of apoptosis in two human leukemia cell lines as well as differentiation in human promyelocytic cells by cyanidin-3-O-β-glucopyranoside. Biochemical pharmacology, v. 67, n. 11, p. 2047-2056, 2004. ISSN 0006-2952. FITZPATRICK, D. F.; HIRSCHFIELD, S. L.; COFFEY, R. G. Endothelium-dependent vasorelaxing activity of wine and other grape products. American Journal of Physiology-Heart and Circulatory Physiology, v. 265, n. 2, p. H774-H778, 1993. ISSN 0363-6135. FORESTER, S. C. et al. The anthocyanin metabolites gallic acid, 3‐O‐methylgallic acid, and 2, 4, 6‐trihydroxybenzaldehyde decrease human colon cancer cell viability by regulating pro‐oncogenic signals. Molecular carcinogenesis, v. 53, n. 6, p. 432-439, 2014. ISSN 0899-1987. FÖRSTERMANN, U.; SESSA, W. C. Nitric oxide synthases: regulation and function. European heart journal, v. 33, n. 7, p. 829-837, 2011. ISSN 1522-9645. FOSSEN, T. et al. Characteristic anthocyanin pattern from onions and other Allium spp. Journal of Food Science, v. 61, n. 4, p. 703-706, 1996. ISSN 0022-1147. FURUTA, S. et al. High tert-butylperoxyl radical scavenging activities of sweet potato cultivars with purple flesh. Food Science and Technology International, Tokyo, v. 4, n. 1, p. 33-35, 1998. ISSN 1341-7592. GAO, M. et al. Microwave-assisted extraction of scutellarin from Erigeron breviscapus Hand-Mazz and its determination by high-performance liquid chromatography. Analytica chimica acta, v. 591, n. 2, p. 161-166, 2007. ISSN 0003-2670. GARCıIA‐VIGUERA, C.; ZAFRILLA, P.; TOMÁS‐BARBERÁN, F. A. Determination of authenticity of fruit jams by HPLC analysis of anthocyanins. Journal of the Science of Food and Agriculture, v. 73, n. 2, p. 207-213, 1997. ISSN 0022-5142. GENNARO, L. et al. Flavonoid and carbohydrate contents in Tropea red onions: effects of homelike peeling and storage. Journal of Agricultural and Food Chemistry, v. 50, n. 7, p. 1904-1910, 2002. ISSN 0021-8561. GHOSH, D.; KONISHI, T. Anthocyanins and anthocyanin-rich extracts: role in diabetes and eye function. Asia Pacific journal of clinical nutrition, v. 16, n. 2, p. 200-208, 2007. ISSN 0964-7058. GIL, M. I. et al. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. Journal of Agricultural and Food chemistry, v. 48, n. 10, p. 4581-4589, 2000. ISSN 0021-8561. GIUSTI, M. M.; WROLSTAD, R. E. Acylated anthocyanins from edible sources and their applications in food systems. Biochemical Engineering Journal, v. 14, n. 3, p. 217-225, 2003. ISSN 1369-703X. GOODWIN, T. W. Chemistry and biochemistry of plant pigments. Chemistry and biochemistry of plant pigments., 1965. GRACE, M. H. et al. Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton. Phytomedicine, v. 16, n. 5, p. 406-415, 2009. ISSN 0944-7113. HÄKKINEN, S.; AURIOLA, S. High-performance liquid chromatography with electrospray ionization mass spectrometry and diode array ultraviolet detection in the identification of flavonol aglycones and glycosides in berries. Journal of Chromatography A, v. 829, n. 1-2, p. 91-100, 1998. ISSN 0021-9673. HARBORNE, J.; HALL, E. Plant polyphenols-XIII.: The systematic distribution and origin of anthocyanins containing branched trisaccharides. Phytochemistry, v. 3, n. 3, p. 453-463, 1964. ISSN 0031-9422. HARBORNE, J. B.; WILLIAMS, C. A. Anthocyanins and other flavonoids. Natural product reports, v.18, n. 3, p. 310-333, 2001. HEISS, E. et al. Nuclear factor-κB is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. Journal of Biological Chemistry, 2001. ISSN 0021-9258. HERRMANN, K. Flavonols and flavones in food plants: a review. International Journal of Food Science & Technology, v. 11, n. 5, p. 433-448, 1976. ISSN 0950-5423. HOLLMAN, P. C. H. Evidence for health benefits of plant phenols: local or systemic effects? Journal of the Science of Food and Agriculture, v. 81, n. 9, p. 842-852, 2001. ISSN 1097-0010. HORBOWICZ, M. et al. Anthocyanins of fruits and vegetables-their occurrence, analysis and role in human nutrition. Vegetable crops research bulletin, v. 68, p. 5-22, 2008. ISSN 1898-7761. ITO, F. et al. Why do flavylium salts show so various colors in solution?: Effect of concentration and water on the flavylium’s color changes. Journal of Photochemistry and Photobiology A: Chemistry, v. 150, n. 1-3, p. 153-157, 2002. ISSN 1010-6030. IVERSEN, C. K. Black currant nectar: effect of processing and storage on anthocyanin and ascorbic acid content. Journal of Food Science, v. 64, n. 1, p. 37-41, 1999. ISSN 0022-1147. JAYAPRAKASAM, B. et al. Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. Journal of Agricultural and Food Chemistry, v. 53, n. 1, p. 28-31, 2005. ISSN 0021-8561. JEON, Y.-D. et al. The Effect of Aronia Berry on Type 1 Diabetes in vivo and in vitro. Journal of medicinal food, v. 21, n. 3, p. 244-253, 2018. ISSN 1096-620X. KÄHKÖNEN, M. P.; HOPIA, A. I.; HEINONEN, M. Berry phenolics and their antioxidant activity. J. Agric. Food Chem., 49:4076–4082., 2001. KALT, W. et al. Interspecific variation in anthocyanins, phenolics, and antioxidant capacity among genotypes of highbush and lowbush blueberries (Vaccinium section cyanococcus spp.). Journal of agricultural and food chemistry, v. 49, n. 10, p. 4761-4767, 2001. ISSN 0021-8561. KHAN, M. S. et al. Anthocyanins protect against LPS-induced oxidative stress-mediated neuroinflammation and neurodegeneration in the adult mouse cortex. Neurochemistry international, v. 100, p. 1-10, 2016. ISSN 0197-0186. KONCZAK, I.; ZHANG, W. Anthocyanins—more than nature's colours. BioMed Research International, v. 2004, n. 5, p. 239-240, 2004. ISSN 1110-7243. KONG, J.-M. et al. Analysis and biological activities of anthocyanins. Phytochemistry, v. 64, n. 5, p. 923-933, 2003. ISSN 0031-9422. KRUGER, M. J. et al. Proanthocyanidins, anthocyanins and cardiovascular diseases. Food Research International, v. 59, p. 41-52, 2014. ISSN 0963-9969. LEWIS, C. Biochemistry and regulation of anthocyanin synthesis in potato and other tuber-bearing Solanum species. 1996. Ph. D. thesis, Dept. of Plant & Plant Microbial Science, Univ. of Canterbury, Christchurch, New Zealand LI, D. et al. Polyphenols, anthocyanins, and flavonoids contents and the antioxidant capacity of various cultivars of highbush and half-high blueberries. Journal of Food Composition and Analysis, v. 62, p. 84-93, 2017. ISSN 0889-1575. LI, H.; FORSTERMANN, U. Prevention of atherosclerosis by interference with the vascular nitric oxide system. Current pharmaceutical design, v. 15, n. 27, p. 3133-3145, 2009. ISSN 1389-2002. LIMTRAKUL, P. et al. Suppression of inflammatory responses by black rice extract in RAW 264.7 macrophage cells via downregulation of NF-kB and AP-1 signaling pathways. Asian Pac J Cancer Prev, v. 16, n. 10, p. 4277-4283, 2015. LONG, H.-L. et al. Mulberry anthocyanins improves thyroid cancer progression mainly by inducing apoptosis and autophagy cell death. The Kaohsiung Journal of Medical Sciences, v. 34, n. 5, p. 255-262, 2018. ISSN 1607-551X. MARQUEZ, A.; SERRATOSA, M. P.; MERIDA, J. Pyranoanthocyanin derived pigments in wine: Structure and formation during winemaking. Journal of Chemistry, v. 2013, 2013. ISSN 2090-9063. MATTILA, P. H. et al. Polyphenol and vitamin C contents in European commercial blackcurrant juice products. Food chemistry, v. 127, n. 3, p. 1216-1223, 2011. ISSN 0308-8146. MAZZA, G. Anthocyanins in Fruits, Vegetables, and Grains: 0. CRC press, 2018. ISBN 1351078151. MIGUEL, M. G. Antioxidant activity of medicinal and aromatic plants. A review. Flavour and Fragrance Journal, v. 25, n. 5, p. 291-312, 2010. ISSN 0882-5734. Anthocyanins: antioxidant and/or anti-inflammatory activities. Journal of Applied Pharmaceutical Science, v. 1, n. 6, p. 7-15, 2011. ISSN 2231-3354. MOLONEY, M. et al. Red cabbage anthocyanins: The influence of d-glucose acylation by hydroxycinnamic acids on their structural transformations in acidic to mildly alkaline conditions and on the resulting color. Dyes and Pigments, 2018. ISSN 0143-7208. MOYER, R. A. et al. Anthocyanins, phenolics, and antioxidant capacity in diverse small fruits: Vaccinium, Rubus, and Ribes. Journal of agricultural and food chemistry, v. 50, n. 3, p. 519-525, 2002. ISSN 0021-8561. NAKAMURA, Y.; MATSUMOTO, H.; TODOKI, K. Endothelium-dependent vasorelaxation induced by black currant concentrate in rat thoracic aorta. The Japanese journal of pharmacology, v. 89, n. 1, p. 29-35, 2002. ISSN 0021-5198. NYMAN, A. N.; KUMPULAINEN, J. T. Determination of anthocyanidins in berries and red wine by high-performance liquid chromatography. J. Agric. Food Chem., 49:4183–4187., 2001. OSZMIAŃSKI, J. et al. Effect of dried powder preparation process on polyphenolic content and antioxidant capacity of cranberry (Vaccinium macrocarpon L.). Industrial Crops and Products, v. 77, p.658-665, 2015. ISSN 0926-6690. PISSARRA, J. et al. Formation of new anthocyanin-alkyl/aryl-flavanol pigments in model solutions. Analytica Chimica Acta, v. 513, n. 1, p. 215-221, 2004. ISSN 0003-2670. PRIOR, R. L. et al. Identification of procyanidins and anthocyanins in blueberries and cranberries (Vaccinium spp.) using high-performance liquid chromatography/mass spectrometry. Journal of agricultural and food chemistry, v. 49, n. 3, p. 1270-1276, 2001. ISSN 0021-8561. REDDIVARI, L. et al. Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways. Carcinogenesis, v. 28, n. 10, p. 2227-2235, 2007. ISSN 1460-2180. RODRIGUEZ‐SAONA, L. E.; GIUSTI, M. M.; WROLSTAD, R. E. Anthocyanin pigment composition of red‐fleshed potatoes. Journal of Food Science, v. 63, n. 3, p. 458-465, 1998. ISSN 0022-1147. ROJO, L. E. et al. In vitro and in vivo anti-diabetic effects of anthocyanins from Maqui Berry (Aristotelia chilensis). Food Chemistry, v. 131, n. 2, p. 387-396, 2012. ISSN 0308-8146. ROSENBLAT, M.; HAYEK, T.; AVIRAM, M. Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages. Atherosclerosis, v. 187, n. 2, p. 363-371, 2006. ISSN 0021-9150. RUGINĂ, D. et al. Antioxidant activities of chokeberry extracts and the cytotoxic action of their anthocyanin fraction on HeLa human cervical tumor cells. Journal of medicinal food, v. 15, n. 8, p. 700-706, 2012. ISSN 1096-620X. SARMA, A. D.; SREELAKSHMI, Y.; SHARMA, R. Antioxidant ability of anthocyanins against ascorbic acid oxidation. Phytochemistry, v. 45, n. 4, p. 671-674, 1997. ISSN 0031-9422. SATUÉ-GRACIA, M. T.; HEINONEN, M.; FRANKEL, E. N. Anthocyanins as antioxidants on human low-density lipoprotein and lecithin− liposome systems. Journal of Agricultural and Food Chemistry, v. 45, n. 9, p. 3362-3367, 1997. ISSN 0021-8561. SELLAPPAN, S.; AKOH, C., C., ; KREWER, G. Phenolic compounds and antioxidant capacity of Georgia-grown bluberries and blackberries. J. Agric. Food Chem., 50:2431–2438., 2002. SELLAPPAN, S.; AKOH, C. C. Flavonoids and antioxidant capacity of Georgia-grown Vidalia onions. Journal of Agricultural and Food Chemistry, v. 50, n. 19, p. 5338-5342, 2002. ISSN 0021-8561. SELLAPPAN, S.; AKOH, C. C.; KREWER, G. Phenolic compounds and antioxidant capacity of Georgia-grown blueberries and blackberries. Journal of agricultural and food chemistry, v. 50, n. 8, p. 2432-2438, 2002. ISSN 0021-8561. SINGLETON, V. L. Naturally occurring food toxicants: phenolic substances of plant origin common in foods. In: (Ed.). Advances in food research: Elsevier, v.27, 1981. p.149-242. ISBN 0065-2628. SKATES, E. et al. Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage. Food and Chemical Toxicology, v. 111, p. 445-453, 2018. ISSN 0278-6915. SLIMESTAD, R.; SOLHEIM, H. Anthocyanins from black currants (Ribes nigrum L.). Journal of Agricultural and Food Chemistry, v. 50, n. 11, p. 3228-3231, 2002. ISSN 0021-8561. STINTZING, F. C. et al. A novel zwitterionic anthocyanin from evergreen blackberry (Rubus laciniatus Willd.). Journal of agricultural and food chemistry, v. 50, n. 2, p. 396-399, 2002. ISSN 0021-8561. SUDA, I. et al. Direct absorption of acylated anthocyanin in purple-fleshed sweet potato into rats. Journal of agricultural and food chemistry, v. 50, n. 6, p. 1672-1676, 2002. ISSN 0021-8561. SUNTRES, Z. E. Liposomal antioxidants for protection against oxidant-induced damage. Journal of toxicology, v. 2011, 2011. ISSN 1687-8191. SVANBERG, L. et al. Effect of anthocyanins on lipid oxidation and microbial spoilage in value-added emulsions with bilberry seed oil, anthocyanins and cold set whey protein hydrogels. Food chemistry, v. 272, p. 273-278, 2019. ISSN 0308-8146. TAKIKAWA, M. et al. Dietary Anthocyanin-Rich Bilberry Extract Ameliorates Hyperglycemia and Insulin Sensitivity via Activation of AMP-Activated Protein Kinase in Diabetic Mice–3. The Journal of nutrition, v. 140, n. 3, p. 527-533, 2010. ISSN 1541-6100. TSAI, T.-C. et al. An anthocyanin-rich extract from Hibiscus sabdariffa linnaeus inhibits N-nitrosomethylurea-induced leukemia in rats. Journal of agricultural and food chemistry, v. 62, n. 7, p. 1572-1580, 2014. ISSN 0021-8561. TSUDA, T. et al. Dietary cyanidin 3-O-β-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. The Journal of nutrition, v. 133, n. 7, p. 2125-2130, 2003. ISSN 0022-3166. TSUDA, T. et al. Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from Phaseolus vulgaris L. Biochemical Pharmacology, v. 52, n. 7, p. 1033-1039, 1996. ISSN 0006-2952. TÜRKER, N.; ERDOGˇDU, F. Effects of pH and temperature of extraction medium on effective diffusion coefficient of anthocynanin pigments of black carrot (Daucus carota var. L.). Journal of Food Engineering, v. 76, n. 4, p. 579-583, 2006. ISSN 0260-8774. VINSON, J. A. et al. Plant flavonoids, especially tea flavonols, are powerful antioxidants using an in vitro oxidation model for heart disease. Journal of Agricultural and Food Chemistry, v. 43, n. 11, p. 2800-2802, 1995. ISSN 0021-8561. WANG, H.; CAO, G.; PRIOR, R. L. Oxygen radical absorbing capacity of anthocyanins. Journal of agricultural and Food Chemistry, v. 45, n. 2, p. 304-309, 1997. ISSN 0021-8561. WANG, L.; WELLER, C. L. Recent advances in extraction of nutraceuticals from plants. Trends in Food Science & Technology, v. 17, n. 6, p. 300-312, 2006. ISSN 0924-2244. WANG, L. et al. Cranberry anthocyanin as an herbal medicine lowers plasma cholesterol by increasing excretion of fecal sterols. Phytomedicine, v. 38, p. 98-106, 2018. ISSN 0944-7113. WANG, S. Y.; STRETCH, A. W. Antioxidant capacity in cranberry is influenced by cultivar and storage temperature. Journal of Agricultural and Food Chemistry, v. 49, n. 2, p. 969-974, 2001. ISSN 0021-8561. WEI, J. et al. Anthocyanin improving metabolic disorders in obese mice from Aornia melanocarpa. Indian Journal of Pharmaceutical Education and Research, v. 50, n. 3, p. 368-375, 2016. ISSN 0019-5464. XIA, N. et al. Artichoke, cynarin and cyanidin downregulate the expression of inducible nitric oxide synthase in human coronary smooth muscle cells. Molecules, v. 19, n. 3, p. 3654-3668, 2014. YANG, Z. et al. Extraction and identification of anthocyanin from purple corn (Zea mays L.). International journal of food science & technology, v. 44, n. 12, p. 2485-2492, 2009. ISSN 0950-5423. YANG, Z.; ZHAI, W. Optimization of microwave-assisted extraction of anthocyanins from purple corn (Zea mays L.) cob and identification with HPLC–MS. Innovative food science & emerging technologies, v. 11, n. 3, p. 470-476, 2010. ISSN 1466-8564. ZHANG, Y. et al. Insulin secretion and cyclooxygenase enzyme inhibition by cabernet sauvignon grape skin compounds. Journal of agricultural and food chemistry, v. 52, n. 2, p. 228-233, 2004. ISSN 0021-8561. ZHENG, X. et al. Extraction characteristics and optimal parameters of anthocyanin from blueberry powder under microwave-assisted extraction conditions. Separation and Purification Technology, v. 104, p. 17-25, 2013. ISSN 1383-5866. ZHONGDONG, L. et al. Image study of pectin extraction from orange skin assisted by microwave. Carbohydrate polymers, v. 64, n. 4, p. 548-552, 2006. ISSN 0144-8617. ZORENC, Z.; VEBERIC, R.; MIKULIC‐PETKOVSEK, M. Are Processed Bilberry Products a Good Source of Phenolics? Journal of food science, 2018. ISSN 0022-1147. --- CAPITULO II --- Abyari, M., R. Heidari and R. Jamei (2006). "The effect of heating, UV irradiation and PH on stability of Siahe Sardasht Grape anthocyanin–copigment complex." Journal of Biological Science 6(4): 638-645. Ai, T. N., A. H. Naing, M. Arun, S. M. Jeon and C. K. Kim (2017). "Expression of RsMYB1 in Petunia enhances anthocyanin production in vegetative and floral tissues." Scientia Horticulturae 214: 58-65. Al-Fartosy, A. J. and A. A. Abdulwahid (2015). "Antioxidant activity of anthocyanins extracted from Iraqi Iresine herbstii L. flowers after drying and freezing." American Journal of Analytical Chemistry 6(05): 382. Andriambeloson, E., A. L. Kleschyov, B. Muller, A. Beretz, J. C. Stoclet and R. Andriantsitohaina (1997). "Nitric oxide production and endothelium‐dependent vasorelaxation induced by wine polyphenols in rat aorta." British journal of pharmacology 120(6): 1053-1058. Antal, D.-S., G. Garban and Z. Garban (2003). "The anthocyans: biologically-active substances of food and pharmaceutic interest." Annals of the University Dunarea de Jos of Galati, Fascicle VI: Food Technology: 106-115. Anwar, S., D. Fratantonio, D. Ferrari, A. Saija, F. Cimino and A. Speciale (2016). "Berry anthocyanins reduce proliferation of human colorectal carcinoma cells by inducing caspase-3 activation and p21 upregulation." Molecular medicine reports 14(2): 1397-1403. Aqil, F., A. Gupta, R. Munagala, J. Jeyabalan, H. Kausar, R. J. Sharma, I. P. Singh and R. C. Gupta (2012). "Antioxidant and antiproliferative activities of anthocyanin/ellagitannin-enriched extracts from Syzygium cumini L.(Jamun, the Indian Blackberry)." Nutrition and cancer 64(3): 428-438. Azar, M., E. Verette and S. Brun (1987). Identification of some phenolic compounds in bilberry juice Vaccinium myrtillus. J. Food Sci., 52:1255–1257. Azeredo, H. M. (2009). "Betalains: properties, sources, applications, and stability–a review." International journal of food science & technology 44(12): 2365-2376. Barnes, J. S., H. P. Nguyen, S. Shen and K. A. Schug (2009). "General method for extraction of blueberry anthocyanins and identification using high performance liquid chromatography–electrospray ionization-ion trap-time of flight-mass spectrometry." Journal of Chromatography A 1216(23): 4728-4735. Benefield, L. D., J. F. Judkins and B. L. Weand (1982). Process chemistry for water and wastewater treatment, Prentice Hall Inc. Beres, C., F. F. Simas-Tosin, I. Cabezudo, S. P. Freitas, M. Iacomini, C. Mellinger-Silva and L. M. Cabral (2016). "Antioxidant dietary fibre recovery from Brazilian Pinot noir grape pomace." Food chemistry 201: 145-152. Bishayee, A., E. Háznagy-Radnai, T. Mbimba, P. Sipos, P. Morazzoni, A. S. Darvesh, D. Bhatia and J. Hohmann (2010). "Anthocyanin-rich black currant extract suppresses the growth of human hepatocellular carcinoma cells." Natural product communications 5(10): 1613-1618. Bonzanini, F., R. Bruni, G. Palla, N. Serlataite and A. Caligiani (2009). "Identification and distribution of lignans in Punica granatum L. fruit endocarp, pulp, seeds, wood knots and commercial juices by GC–MS." Food Chemistry 117(4): 745-749. Borkowski, T., H. Szymusiak, A. Gliszczyńska-Swigło and B. Tyrakowska (2005). "The effect of 3-O-β-glucosylation on structural transformations of anthocyanidins." Food research international 38(8-9): 1031-1037. Boulton, R. (2001). "The copigmentation of anthocyanins and its role in the color of red wine: a critical review." American journal of enology and viticulture 52(2): 67-87. Brazinha, C., M. Cadima and J. G. Crespo (2014). "Optimization of extraction of bioactive compounds from different types of grape pomace produced at wineries and distilleries." Journal of food science 79(6): E1142-E1149. Bridle, P. and C. Timberlake (1997). "Anthocyanins as natural food colours—selected aspects." Food chemistry 58(1-2): 103-109. Brouillard, R. (1982). Chemical structure of anthocyanins, Academic Press: New York. Brouillard, R. and B. Delaporte (1977). "Chemistry of anthocyanin pigments. 2. Kinetic and thermodynamic study of proton transfer, hydration, and tautomeric reactions of malvidin 3-glucoside." Journal of the American Chemical Society 99(26): 8461-8468. Bunea, A., D. Rugină, Z. Sconţa, R. M. Pop, A. Pintea, C. Socaciu, F. Tăbăran, C. Grootaert, K. Struijs and J. VanCamp (2013). "Anthocyanin determination in blueberry extracts from various cultivars and their antiproliferative and apoptotic properties in B16-F10 metastatic murine melanoma cells." Phytochemistry 95: 436-444. Buran, T. J., A. K. Sandhu, Z. L. Cheryl R. Rock, W. W. Yang and L. Gu (2014). Adsorption/desorption characteristics and separation of anthocyanins and polyphenols from blueberries using macroporous adsorbent resins. Journal of Food Engineering 128 .167–173. DOI: 10.1016/j.jfoodeng.2013.12.029. Buran, T. J., A. K. Sandhu, Z. Li, C. R. Rock, W. W. Yang and L. Gu (2014). "Adsorption/desorption characteristics and separation of anthocyanins and polyphenols from blueberries using macroporous adsorbent resins." Journal of Food Engineering 128: 167-173. Cacace, J. and G. Mazza (2003). "Mass transfer process during extraction of phenolic compounds from milled berries." Journal of Food Engineering 59(4): 379-389. Caldas, T. W., K. E. Mazza, A. S. Teles, G. N. Mattos, A. I. S. Brígida, C. A. Conte-Junior, R. G. Borguini, R. L. Godoy, L. M. Cabral and R. V. Tonon (2018). "Phenolic compounds recovery from grape skin using conventional and non-conventional extraction methods." Industrial crops and products 111: 86-91. Cantos, E., J. C. Espin and F. A. Tomás-Barberán (2001). Effect of wounding on phenolic enzymes in six minimally processed lettuce cultivars upon storage. J. Agric. Food Chem., 49:322–330. Cantos, E., J. C. Espin and F. A. Tomás-Barberán (2002). "Varietal differences among the polyphenol profiles of seven table grape cultivars studied by LC− DAD− MS− MS." Journal of Agricultural and Food Chemistry 50(20): 5691-5696. Castaneda-Ovando, A., M. de Lourdes Pacheco-Hernández, M. E. Páez-Hernández, J. A. Rodríguez and C. A. Galán-Vidal (2009). "Chemical studies of anthocyanins: A review." Food chemistry 113(4): 859-871. Castillo-Munoz, N., M. Fernandez-Gonzalez, S. Gomez-Alonso, E. Garcia-Romero and I. Hermosin-Gutierrez (2009). "Red-color related phenolic composition of Garnacha Tintorera (Vitis vinifera L.) grapes and red wines." Journal of Agricultural and Food Chemistry 57(17): 7883-7891. Cătunescu, G. M., A. M. Rotar, C. R. Pop, Z. Diaconeasa, F. Bunghez, M.-I. Socaciu and C. A. Semeniuc (2019). "Influence of extraction pre-treatments on some phytochemicals and biological activity of Transylvanian cranberries (Vaccinium vitis-idea L.)." LWT 102: 385-392. Chandra, A., J. Rana and Y. Li (2001). Separation, identification, quanatitation, and method validation of anthocyanins in botanical supplement raw materials by HPLC and HPLC-MS. J. Agric. Food Chem., 49:3515–3521. Chandra, A., J. Rana and Y. Li (2001). "Separation, identification, quantification, and method validation of anthocyanins in botanical supplement raw materials by HPLC and HPLC− MS." Journal of agricultural and food chemistry 49(8): 3515-3521. Chandrasekhar, J., M. Madhusudhan and K. Raghavarao (2012). "Extraction of anthocyanins from red cabbage and purification using adsorption." Food and bioproducts processing 90(4): 615-623. Chang, X.-L., D. Wang, B.-Y. Chen, Y.-M. Feng, S.-H. Wen and P.-Y. Zhan (2012). "Adsorption and desorption properties of macroporous resins for anthocyanins from the calyx extract of roselle (Hibiscus sabdariffa L.)." Journal of agricultural and food chemistry 60(9): 2368-2376. Chemat, S., H. Aït-Amar, A. Lagha and D. Esveld (2005). "Microwave-assisted extraction kinetics of terpenes from caraway seeds." Chemical Engineering and Processing: Process Intensification 44(12): 1320-1326. Cheminat, A. and R. Brouillard (1986). "PMR investigation of 3-O-(β-D-glucosyl) malvidin structural transformations in aqueous solutions." Tetrahedron letters 27(37): 4457-4460. Chen, L.-J. and G. Hrazdina (1981). "Structural aspects of anthocyanin-flavonoid complex formation and its role in plant color." Phytochemistry 20(2): 297-303. Chen, L., H. Jin, L. Ding, H. Zhang, J. Li, C. Qu and H. Zhang (2008). "Dynamic microwave-assisted extraction of flavonoids from Herba Epimedii." Separation and Purification Technology 59(1): 50-57. Chen, R., Q. Yang, Y. Zhong, X. Li, Y. Liu, X.-M. Li, W.-X. Du and G.-M. Zeng (2014). "Sorption of trace levels of bromate by macroporous strong base anion exchange resin: Influencing factors, equilibrium isotherms and thermodynamic studies." Desalination 344: 306-312. Chen, Y., W. Zhang, T. Zhao, F. Li, M. Zhang, J. Li, Y. Zou, W. Wang, S. J. Cobbina and X. Wu (2016). "Adsorption properties of macroporous adsorbent resins for separation of anthocyanins from mulberry." Food chemistry 194: 712-722. Chen, Z. B., A. J. Zhang, J. Li, Dong, F, D. L. Di and Y. Z. Wu (2010). Study on the adsorption feature of rutin aqueous solution on macroporous adsorption resins. The Journal of Physical Chemistry, B 114, 4841–4853. DOI: 10.1021/jp910115q. Cheynier and Rigaud (1986). HPLC Separation and Characterization of Flavonols in the Skins of Vitis vinifera var. Cinsault, National Institute of Agronomic Research (INRA), American Journal of Enology and Viticulture,Davis, 37: 248-252. Clifford, M. N. (2000). "Anthocyanins–nature, occurrence and dietary burden." Journal of the Science of Food and Agriculture 80(7): 1063-1072. Colak, N., A. K. Primetta, K. R. Riihinen, L. Jaakola, J. Grúz, M. Strnad, H. Torun and F. A. Ayaz (2017). "Phenolic compounds and antioxidant capacity in different-colored and non-pigmented berries of bilberry (Vaccinium myrtillus L.)." Food Bioscience 20: 67-78. Cook, N. C. and S. Samman (1996). Flavonoids-chemistry, metabolism, cardioprotective effects, and dietary sources. Nutr. Biochem., 7:66–76. Costantino, L., A. Albasini, G. Rastelli and S. Benvenuti (1992). "Activity of polyphenolic crude extracts as scavangers of superoxide radicals and inhibitors of xanthine oxidase." Planta medica 58(04): 342-344. da Costa, C. T., B. C. Nelson, S. A. Margolis and D. Horton (1998). "Separation of blackcurrant anthocyanins by capillary zone electrophoresis." Journal of Chromatography A 799(1-2): 321-327. da Silva, D. F., C. Itoda, C. I. L. F. Rosa, A. C. P. Vital, L. N. Yamamoto, L. Y. Yamamoto, R. V. Botelho and P. T. Matumoto-Pintro (2018). "Effects of blackberries (Rupus sp.; cv. Xavante) processing on its physicochemical properties, phenolic contents and antioxidant activity." Journal of food science and technology 55(11): 4642-4649. Dai, J. and R. J. Mumper (2010). "Plant phenolics: extraction, analysis and their antioxidant and anticancer properties." Molecules 15(10): 7313-7352. Dai, J. and R. J. Mumper (2010). "Plant phenolics: Extraction, analysis and their antioxidant and anticancer properties. Molecules, 15, 7313–7352. DOI: 10.3390/molecules15107313." de Rosso, V. V., S. Hillebrand, E. C. Montilla, F. O. Bobbio, P. Winterhalter and A. Z. Mercadante (2008). "Determination of anthocyanins from acerola (Malpighia emarginata DC.) and açai (Euterpe oleracea Mart.) by HPLC–PDA–MS/MS." Journal of Food Composition and Analysis 21(4): 291-299. DeFuria, J., G. Bennett, K. J. Strissel, J. W. Perfield, P. E. Milbury, A. S. Greenberg and M. S. Obin (2009). "Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae." The Journal of nutrition 139(8): 1510-1516. Devasagayam, T., J. Tilak, K. Boloor, K. S. Sane, S. S. Ghaskadbi and R. Lele (2004). "Free radicals and antioxidants in human health: current status and future prospects." Japi 52(794804): 4. Devi, P. S., M. S. Kumar and S. M. Das (2011). "Evaluation of antiproliferative activity of red sorghum bran anthocyanin on a human breast cancer cell line (mcf-7)." International journal of breast cancer 2011. Donner, H., L. Gao and G. Mazza (1997). "Separation and characterization of simple and malonylated anthocyanins in red onions, Allium cepa L." Food Research International 30(8): 637-643. Du, C., P. Wang and F. Francis (1975). "Anthocyanins of pomegranate, Punica granatum." Journal of Food Science 40(2): 417-418. Duran, C., D. Ozdes, A. Gundogdu and H. B. Senturk (2011). "Kinetics and isotherm analysis of basic dyes adsorption onto almond shell (Prunus dulcis) as a low cost adsorbent." Journal of Chemical & Engineering Data 56(5): 2136-2147. Ehlenfeldt, M. K. and R. L. Prior (2001). "Oxygen radical absorbance capacity (ORAC) and phenolic and anthocyanin concentrations in fruit and leaf tissues of highbush blueberry." Journal of Agricultural and Food Chemistry 49(5): 2222-2227. Fan-Chiang, H.-j. (1999). "Anthocyanin pigment, nonvolatile acid and sugar composition of blackberries." Fan, G., Y. Han, Z. Gu and D. Chen (2008). "Optimizing conditions for anthocyanins extraction from purple sweet potato using response surface methodology (RSM)." LWT-Food Science and Technology 41(1): 155-160. Fan, L., Y. Wang, P. Xie, L. Zhang, Y. Li and J. Zhou (2019). "Copigmentation effects of phenolics on color enhancement and stability of blackberry wine residue anthocyanins: Chromaticity, kinetics and structural simulation." Food chemistry 275: 299-308. Farías-Campomanes, A. M., M. A. Rostagno and M. A. A. Meireles (2013). "Production of polyphenol extracts from grape bagasse using supercritical fluids: yield, extract composition and economic evaluation." The Journal of Supercritical Fluids 77: 70-78. Filipiak, K., M. Hidalgo, J. M. Silvan, B. Fabre, R. J. Carbajo, A. Pineda-Lucena, A. Ramos, B. de Pascual-Teresa and S. de Pascual-Teresa (2014). "Dietary gallic acid and anthocyanin cytotoxicity on human fibrosarcoma HT1080 cells. A study on the mode of action." Food & function 5(2): 381-389. Fimognari, C., F. Berti, M. Nüsse, G. Cantelli-Forti and P. Hrelia (2004). "Induction of apoptosis in two human leukemia cell lines as well as differentiation in human promyelocytic cells by cyanidin-3-O-β-glucopyranoside." Biochemical pharmacology 67(11): 2047-2056. Fitzpatrick, D. F., S. L. Hirschfield and R. G. Coffey (1993). "Endothelium-dependent vasorelaxing activity of wine and other grape products." American Journal of Physiology-Heart and Circulatory Physiology 265(2): H774-H778. Fontana, A. R., A. Antoniolli and R. n. Bottini (2013). "Grape pomace as a sustainable source of bioactive compounds: extraction, characterization, and biotechnological applications of phenolics." Journal of agricultural and food chemistry 61(38): 8987-9003. Forester, S. C., Y. Y. Choy, A. L. Waterhouse and P. I. Oteiza (2014). "The anthocyanin metabolites gallic acid, 3‐O‐methylgallic acid, and 2, 4, 6‐trihydroxybenzaldehyde decrease human colon cancer cell viability by regulating pro‐oncogenic signals." Molecular carcinogenesis 53(6): 432-439. Förstermann, U. and W. C. Sessa (2011). "Nitric oxide synthases: regulation and function." European heart journal 33(7): 829-837. FOSSEN, T., Ø. M. ANDERSEN, D. O. ØVSTEDAL, A. T. PEDERSEN and Å. RAKNES (1996). "Characteristic anthocyanin pattern from onions and other Allium spp." Journal of Food Science 61(4): 703-706. Fu, B., J. Liu, H. Li, L. Li, F. S. C. Lee and X. Wang (2005). Theapplication of macroporous resins in the separation of licoriceflavonoids and glycyrrhizic acid. J. Chromatogr. A 1089 (1–2),18–24. Fu, Y., Y. Zu, S. Li, R. Sun, T. Efferth, W. Liu, S. Jiang, H. Luo and Y. Wang (2008). "Separation of 7-xylosyl-10-deacetyl paclitaxel and 10-deacetylbaccatin III from the remainder extracts free of paclitaxel using macroporous resins." Journal of Chromatography A 1177(1): 77-86. Fu, Y., Y. Zu, W. Liu, T. Efferth, N. Zhang, X. Liu and Y. Kong (2006). "Optimization of luteolin separation from pigeonpea [Cajanus cajan (L.) Millsp.] leaves by macroporous resins." Journal of Chromatography A 1137(2): 145-152. Furuta, S., I. Suda, Y. Nishiba and O. YAMAKAWA (1998). "High tert-butylperoxyl radical scavenging activities of sweet potato cultivars with purple flesh." Food Science and Technology International, Tokyo 4(1): 33-35. Gao, M., W. Huang, M. RoyChowdhury and C. Liu (2007). "Microwave-assisted extraction of scutellarin from Erigeron breviscapus Hand-Mazz and its determination by high-performance liquid chromatography." Analytica chimica acta 591(2): 161-166. Gao, Z. P., Z. F. Yu, T. L. Yue and S. Y. Quek (2013). "Adsorption isotherm, thermodynamics and kinetics studies of polyphenols separation from kiwifruit juice using adsorbent resin." Journal of Food Engineering 116(1): 195-201. Garcıia‐Viguera, C., P. Zafrilla and F. A. Tomás‐Barberán (1997). "Determination of authenticity of fruit jams by HPLC analysis of anthocyanins." Journal of the Science of Food and Agriculture 73(2): 207-213. Gennaro, L., C. Leonardi, F. Esposito, M. Salucci, G. Maiani, G. Quaglia and V. Fogliano (2002). "Flavonoid and carbohydrate contents in Tropea red onions: effects of homelike peeling and storage." Journal of Agricultural and Food Chemistry 50(7): 1904-1910. Ghosh, D. and T. Konishi (2007). "Anthocyanins and anthocyanin-rich extracts: role in diabetes and eye function." Asia Pacific journal of clinical nutrition 16(2): 200-208. Gil, M. I., F. A. Tomás-Barberán, B. Hess-Pierce, D. M. Holcroft and A. A. Kader (2000). "Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing." Journal of Agricultural and Food chemistry 48(10): 4581-4589. Giusti, M. M., L. E. Rodríguez-Saona and R. E. Wrolstad (1999). "Molar absorptivity and color characteristics of acylated and non-acylated pelargonidin-based anthocyanins." Journal of Agricultural and Food Chemistry 47(11): 4631-4637. Giusti, M. M. and R. E. Wrolstad (2001). "Characterization and measurement of anthocyanins by UV‐visible spectroscopy." Current protocols in food analytical chemistry(1): F1. 2.1-F1. 2.13. Giusti, M. M. and R. E. Wrolstad (2003). "Acylated anthocyanins from edible sources and their applications in food systems." Biochemical Engineering Journal 14(3): 217-225. Goodwin, T. W. (1965). "Chemistry and biochemistry of plant pigments." Chemistry and biochemistry of plant pigments. Goupy, P. M., P. J. Varoquaux, J. J. Nicolas and J. J. Macheix (1990). "Identification and localization of hydroxycinnamoyl and flavonol derivatives from endive (Cichorium endivia L. cv. Geante Maraichere) leaves." Journal of agricultural and food chemistry 38(12): 2116-2121. Gouvêa, A. C. M. S., M. C. P. d. Araujo, D. F. Schulz, S. Pacheco, R. L. d. O. Godoy and L. M. C. Cabral (2012). "Anthocyanins standards (cyanidin-3-O-glucoside and cyanidin-3-O-rutinoside) isolation from freeze-dried açaí (Euterpe oleraceae Mart.) by HPLC." Food Science and Technology 32(1): 43-46. Grace, M. H., D. M. Ribnicky, P. Kuhn, A. Poulev, S. Logendra, G. G. Yousef, I. Raskin and M. A. Lila (2009). "Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton." Phytomedicine 16(5): 406-415. Häkkinen, S. and S. Auriola (1998). "High-performance liquid chromatography with electrospray ionization mass spectrometry and diode array ultraviolet detection in the identification of flavonol aglycones and glycosides in berries." Journal of Chromatography A 829(1-2): 91-100. Harborne, J. (1967). "Comparative biochemistry of the flavonoids Acad." Press, London: 1. Harborne, J. B. and C. A. Williams (2001). "Anthocyanins and other flavonoids." Natural product reports 18(3): 310-333. Heinonen, J., H. Farahmandazad, A. Vuorinen, H. Kallio, B. Yang and T. Sainio (2016). "Extraction and purification of anthocyanins from purple-fleshed potato." Food and bioproducts processing 99: 136-146. Herrmann, K. (1976). "Flavonols and flavones in food plants: a review." International Journal of Food Science & Technology 11(5): 433-448. Hollman, P. C. H. (2001). "Evidence for health benefits of plant phenols: local or systemic effects?" Journal of the Science of Food and Agriculture 81(9): 842-852. Hong, V. and R. E. Wrolstad (1990). "Characterization of anthocyanin-containing colorants and fruit juices by HPLC/photodiode array detection." Journal of Agricultural and Food Chemistry 38(3): 698-708. Horbowicz, M., R. Kosson, A. Grzesiuk and H. Dębski (2008). "Anthocyanins of fruits and vegetables-their occurrence, analysis and role in human nutrition." Vegetable crops research bulletin 68: 5-22. Huang, D., B. Ou and R. L. Prior (2005). "The chemistry behind antioxidant capacity assays." Journal of agricultural and food chemistry 53(6): 1841-1856. Huang, L., Y. Sun, W. Wang, Q. Yue and T. Yang (2011). "Comparative study on characterization of activated carbons prepared by microwave and conventional heating methods and application in removal of oxytetracycline (OTC)." Chemical Engineering Journal 171(3): 1446-1453. Ito, F., N. Tanaka, A. Katsuki and T. Fujii (2002). "Why do flavylium salts show so various colors in solution?: Effect of concentration and water on the flavylium’s color changes." Journal of Photochemistry and Photobiology A: Chemistry 150(1-3): 153-157. Iversen, C. K. (1999). "Black currant nectar: effect of processing and storage on anthocyanin and ascorbic acid content." Journal of Food Science 64(1): 37-41. Jampani, C., A. Naik and K. Raghavarao (2014). "Purification of anthocyanins from jamun (Syzygium cumini L.) employing adsorption." Separation and Purification Technology 125: 170-178. Jayaprakasam, B., S. K. Vareed, L. K. Olson and M. G. Nair (2005). "Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits." Journal of Agricultural and Food Chemistry 53(1): 28-31. Jeon, Y.-D., S.-H. Kang, K.-H. Moon, J.-H. Lee, D.-G. Kim, W. Kim, J.-S. Kim, B.-Y. Ahn and J.-S. Jin (2018). "The Effect of Aronia Berry on Type 1 Diabetes in vivo and in vitro." Journal of medicinal food 21(3): 244-253. Jia, G. and X. Lu (2008). "Enrichment and purification of madecassoside and asiaticoside from Centella asiatica extracts with macroporous resins." Journal of Chromatography A 1193(1-2): 136-141. Jiang, T., Y. Mao, L. Sui, N. Yang, S. Li, Z. Zhu, C. Wang, S. Yin, J. He and Y. He (2019). "Degradation of anthocyanins and polymeric color formation during heat treatment of purple sweet potato extract at different pH." Food chemistry 274: 460-470. Kähkönen, M. P., A. I. Hopia and M. Heinonen (2001). Berry phenolics and their antioxidant activity. J. Agric. Food Chem., 49:4076–4082. Kalt, W., D. A. Ryan, J. C. Duy, R. L. Prior, M. K. Ehlenfeldt and S. Vander Kloet (2001). "Interspecific variation in anthocyanins, phenolics, and antioxidant capacity among genotypes of highbush and lowbush blueberries (Vaccinium section cyanococcus spp.)." Journal of agricultural and food chemistry 49(10): 4761-4767. Kammerer, D., J. G. Kljusuric, R. Carle and A. Schieber (2005). "Recovery of anthocyanins from grape pomace extracts (Vitis vinifera L. cv. Cabernet Mitos) using a polymeric adsorber resin." European Food Research and Technology 220(3-4): 431-437. Kammerer, D. R., J. Kammerer, R. Valet and R. Carle (2014). "Recovery of polyphenols from the by-products of plant food processing and application as valuable food ingredients." Food Research International 65: 2-12. Khan, M. S., T. Ali, M. W. Kim, M. H. Jo, M. G. Jo, H. Badshah and M. O. Kim (2016). "Anthocyanins protect against LPS-induced oxidative stress-mediated neuroinflammation and neurodegeneration in the adult mouse cortex." Neurochemistry international 100: 1-10. Klisurova, D., I. Petrova, M. Ognyanov, Y. Georgiev, M. Kratchanova and P. Denev (2019). "Co-pigmentation of black chokeberry (Aronia melanocarpa) anthocyanins with phenolic co-pigments and herbal extracts." Food chemistry 279: 162-170. Konczak, I. and W. Zhang (2004). "Anthocyanins—more than nature's colours." BioMed Research International 2004(5): 239-240. Kong, J.-M., L.-S. Chia, N.-K. Goh, T.-F. Chia and R. Brouillard (2003). "Analysis and biological activities of anthocyanins." Phytochemistry 64(5): 923-933. Krga, I. and D. Milenkovic (2019). "Anthocyanins: from sources and bioavailability to cardiovascular health benefits and molecular mechanisms of action." Journal of agricultural and food chemistry. Kruger, M. J., N. Davies, K. H. Myburgh and S. Lecour (2014). "Proanthocyanidins, anthocyanins and cardiovascular diseases." Food Research International 59: 41-52. Lavelli, V., P. S. S. Harsha, M. Laureati and E. Pagliarini (2017). "Degradation kinetics of encapsulated grape skin phenolics and micronized grape skins in various water activity environments and criteria to develop wide-ranging and tailor-made food applications." Innovative food science & emerging technologies 39: 156-164. Legua, P., M. Á. Forner-Giner, N. Nuncio-Jáuregui and F. Hernández (2016). "Polyphenolic compounds, anthocyanins and antioxidant activity of nineteen pomegranate fruits: A rich source of bioactive compounds." Journal of functional foods 23: 628-636. Lewis, C. (1996). Biochemistry and regulation of anthocyanin synthesis in potato and other tuber-bearing Solanum species, Ph. D. thesis, Dept. of Plant & Plant Microbial Science, Univ. of Canterbury, Christchurch, New Zealand. Li, D., B. Li, Y. Ma, X. Sun, Y. Lin and X. Meng (2017). "Polyphenols, anthocyanins, and flavonoids contents and the antioxidant capacity of various cultivars of highbush and half-high blueberries." Journal of Food Composition and Analysis 62: 84-93. Li, H. and U. Forstermann (2009). "Prevention of atherosclerosis by interference with the vascular nitric oxide system." Current pharmaceutical design 15(27): 3133-3145. Limtrakul, P., S. Yodkeeree, P. Pitchakarn and W. Punfa (2015). "Suppression of inflammatory responses by black rice extract in RAW 264.7 macrophage cells via downregulation of NF-kB and AP-1 signaling pathways." Asian Pac J Cancer Prev 16(10): 4277-4283. Lin, S.-H. and R.-S. Juang (2009). "Adsorption of phenol and its derivatives from water using synthetic resins and low-cost natural adsorbents: a review." Journal of environmental management 90(3): 1336-1349. Liu, J., J. Luo, Y. Sun, H. Ye, Z. Lu and X. Zeng (2010). "A simple method for the simultaneous decoloration and deproteinization of crude levan extract from Paenibacillus polymyxa EJS-3 by macroporous resin." Bioresource technology 101(15): 6077-6083. Liu, S., X. Chang, X. Liu and Z. Shen (2016). "Effects of pretreatments on anthocyanin composition, phenolics contents and antioxidant capacities during fermentation of hawthorn (Crataegus pinnatifida) drink." Food chemistry 212: 87-95. Liu, W., S. Zhang, Y.-G. Zu, Y.-J. Fu, W. Ma, D.-Y. Zhang, Y. Kong and X.-J. Li (2010). "Preliminary enrichment and separation of genistein and apigenin from extracts of pigeon pea roots by macroporous resins." Bioresource technology 101(12): 4667-4675. Liu, Y., J. Liu, X. Chen, Y. Liu and D. Di (2010). "Preparative separation and purification of lycopene from tomato skins extracts by macroporous adsorption resins." Food Chemistry 123(4): 1027-1034. Long, H.-L., F.-F. Zhang, H.-L. Wang, W.-S. Yang, H.-T. Hou, J.-K. Yu and B. Liu (2018). "Mulberry anthocyanins improves thyroid cancer progression mainly by inducing apoptosis and autophagy cell death." The Kaohsiung Journal of Medical Sciences 34(5): 255-262. Ma, C., G. Tao, Z. Lou, H. Wang, X. Gu, L. Hu and M. Yin (2009). "Preparative separation and purification of rosavin in Rhodiola rosea by macroporous adsorption resins." Separation and Purification Technology 69(1): 22-28. Marquez, A., M. P. Serratosa and J. Merida (2013). "Pyranoanthocyanin derived pigments in wine: Structure and formation during winemaking." Journal of Chemistry 2013. Mattila, P. H., J. Hellström, G. McDougall, G. Dobson, J.-M. Pihlava, T. Tiirikka, D. Stewart and R. Karjalainen (2011). "Polyphenol and vitamin C contents in European commercial blackcurrant juice products." Food chemistry 127(3): 1216-1223. Mazza, G. (2018). Anthocyanins in Fruits, Vegetables, and Grains: 0, CRC press. Miguel, M. G. (2010). "Antioxidant activity of medicinal and aromatic plants. A review." Flavour and Fragrance Journal 25(5): 291-312. Miguel, M. G. (2011). "Anthocyanins: antioxidant and/or anti-inflammatory activities." Journal of Applied Pharmaceutical Science 1(6): 7-15. Moloney, M., R. J. Robbins, T. M. Collins, T. Kondo, K. Yoshida and O. Dangles (2018). "Red cabbage anthocyanins: The influence of d-glucose acylation by hydroxycinnamic acids on their structural transformations in acidic to mildly alkaline conditions and on the resulting color." Dyes and Pigments. Moncayo, J. R. and J.-M. Aurand (2016 ). TABLE AND DRIED GRAPES, FAO and OIV, ISBN 978-92-5-109708-3 (FAO) ,ISBN 979-10-91799-74-4 (OIV). Morello, M. J., F. Shahidi and C.-T. Ho (2002). Free radicals in foods: chemistry, nutrition, and health effects, ACS Publications. Moustaka, J., E. Panteris, I.-D. S. Adamakis, G. Tanou, A. Giannakoula, E. P. Eleftheriou and M. Moustakas (2018). "High anthocyanin accumulation in poinsettia leaves is accompanied by thylakoid membrane unstacking, acting as a photoprotective mechanism, to prevent ROS formation." Environmental and Experimental Botany 154: 44-55. Moyer, R. A., K. E. Hummer, C. E. Finn, B. Frei and R. E. Wrolstad (2002). "Anthocyanins, phenolics, and antioxidant capacity in diverse small fruits: Vaccinium, Rubus, and Ribes." Journal of agricultural and food chemistry 50(3): 519-525. Nakamura, Y., H. Matsumoto and K. Todoki (2002). "Endothelium-dependent vasorelaxation induced by black currant concentrate in rat thoracic aorta." The Japanese journal of pharmacology 89(1): 29-35. Nathália da R. Rodrigues, J. L. B. Junior and L. G. Maria Ivone M. J. Barbosa (2018). "Adsorption and desorption characteristics and separation of phenolic compounds from organic purple-fleshed sweet potatoes (Ipomoea batatas L.) leaves using macroporous resins." Nyman, A. N. and J. T. Kumpulainen (2001). Determination of anthocyanidins in berries and red wine by high-performance liquid chromatography. J. Agric. Food Chem., 49:4183–4187. Oszmiański, J., J. Kolniak-Ostek, S. Lachowicz, J. Gorzelany and N. Matłok (2015). "Effect of dried powder preparation process on polyphenolic content and antioxidant capacity of cranberry (Vaccinium macrocarpon L.)." Industrial Crops and Products 77: 658-665. Pissarra, J., S. Lourenço, A. M. González-Paramás, N. Mateus, C. Santos-Buelga and V. De Freitas (2004). "Formation of new anthocyanin-alkyl/aryl-flavanol pigments in model solutions." Analytica Chimica Acta 513(1): 215-221. Prior, R. L., S. A. Lazarus, G. Cao, H. Muccitelli and J. F. Hammerstone (2001). "Identification of procyanidins and anthocyanins in blueberries and cranberries (Vaccinium spp.) using high-performance liquid chromatography/mass spectrometry." Journal of agricultural and food chemistry 49(3): 1270-1276. Rakić, V., Å. Rinnan, T. Polak, M. Skrt, M. Miljković and N. P. Ulrih (2019). "pH-induced structural forms of cyanidin and cyanidin 3-O-β-glucopyranoside." Dyes and Pigments. Reddivari, L., J. Vanamala, S. Chintharlapalli, S. H. Safe and J. C. Miller Jr (2007). "Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways." Carcinogenesis 28(10): 2227-2235. Rinaldi, M., A. Caligiani, R. Borgese, G. Palla, D. Barbanti and R. Massini (2013). "The effect of fruit processing and enzymatic treatments on pomegranate juice composition, antioxidant activity and polyphenols content." LWT-Food Science and Technology 53(1): 355-359. Rojo, L. E., D. Ribnicky, S. Logendra, A. Poulev, P. Rojas-Silva, P. Kuhn, R. Dorn, M. H. Grace, M. A. Lila and I. Raskin (2012). "In vitro and in vivo anti-diabetic effects of anthocyanins from Maqui Berry (Aristotelia chilensis)." Food Chemistry 131(2): 387-396. Romani, A., N. Mulinacci, P. Pinelli, F. F. Vincieri and A. Cimato (1999). "Polyphenolic content in five tuscany cultivars of Olea europaea L." Journal of Agricultural and Food Chemistry 47(3): 964-967. Rosenblat, M., T. Hayek and M. Aviram (2006). "Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages." Atherosclerosis 187(2): 363-371. Rugină, D., Z. Sconţa, L. Leopold, A. Pintea, A. Bunea and C. Socaciu (2012). "Antioxidant activities of chokeberry extracts and the cytotoxic action of their anthocyanin fraction on HeLa human cervical tumor cells." Journal of medicinal food 15(8): 700-706. Ruíz-García, Y., C. Beres, D. W. Chávez, E. F. Souza, R. V. Tonon and L. M. Cabral (2019). "Influence of processing conditions on bioactive compound extraction from Vitis vinifera L. var. Alicante Bouschet grape skin." Journal of food science and technology 56(2): 1066-1072. Sadilova, E., F. Stintzing and R. Carle (2006). "Thermal degradation of acylated and nonacylated anthocyanins." Journal of food science 71(8): C504-C512. Sandhu, A. K. and L. Gu (2013). "Adsorption/desorption characteristics and separation of anthocyanins from muscadine (Vitis rotundifolia) juice pomace by use of macroporous adsorbent resins." Journal of agricultural and food chemistry 61(7): 1441-1448. Sarma, A. D., Y. Sreelakshmi and R. Sharma (1997). "Antioxidant ability of anthocyanins against ascorbic acid oxidation." Phytochemistry 45(4): 671-674. Satué-Gracia, M. T., M. Heinonen and E. N. Frankel (1997). "Anthocyanins as antioxidants on human low-density lipoprotein and lecithin− liposome systems." Journal of Agricultural and Food Chemistry 45(9): 3362-3367. Sellappan, S., C. Akoh, C., and G. Krewer (2002). Phenolic compounds and antioxidant capacity of Georgia-grown bluberries and blackberries. J. Agric. Food Chem., 50:2431–2438. Sellappan, S. and C. C. Akoh (2002). "Flavonoids and antioxidant capacity of Georgia-grown Vidalia onions." Journal of Agricultural and Food Chemistry 50(19): 5338-5342. Sellappan, S., C. C. Akoh and G. Krewer (2002). "Phenolic compounds and antioxidant capacity of Georgia-grown blueberries and blackberries." Journal of agricultural and food chemistry 50(8): 2432-2438. Silva, E., D. Pompeu, Y. Larondelle and H. Rogez (2007). "Optimisation of the adsorption of polyphenols from Inga edulis leaves on macroporous resins using an experimental design methodology." Separation and Purification Technology 53(3): 274-280. Singleton, V. L. (1981). Naturally occurring food toxicants: phenolic substances of plant origin common in foods. Advances in food research, Elsevier. 27: 149-242. Skates, E., J. Overall, K. DeZego, M. Wilson, D. Esposito, M. A. Lila and S. Komarnytsky (2018). "Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage." Food and Chemical Toxicology 111: 445-453. Slimestad, R. and H. Solheim (2002). "Anthocyanins from black currants (Ribes nigrum L.)." Journal of Agricultural and Food Chemistry 50(11): 3228-3231. Stanton, W. and B. Francis (1966). "Ecological significance of anthocyanins in the seed coats of the Phaseoleae." Nature 211(5052): 970. Stintzing, F. C., A. S. Stintzing, R. Carle and R. E. Wrolstad (2002). "A novel zwitterionic anthocyanin from evergreen blackberry (Rubus laciniatus Willd.)." Journal of agricultural and food chemistry 50(2): 396-399. Su, C.-C., C.-J. Wang, K.-H. Huang, Y.-J. Lee, W.-M. Chan and Y.-C. Chang (2018). "Anthocyanins from Hibiscus sabdariffa calyx attenuate in vitro and in vivo melanoma cancer metastasis." Journal of Functional Foods 48: 614-631. Suda, I., T. Oki, M. Masuda, Y. Nishiba, S. Furuta, K. Matsugano, K. Sugita and N. Terahara (2002). "Direct absorption of acylated anthocyanin in purple-fleshed sweet potato into rats." Journal of agricultural and food chemistry 50(6): 1672-1676. Sun, J., X. Cao, X. Liao and X. Hu (2010). "Comparative analyses of copigmentation of cyanidin 3-glucoside and cyanidin 3-sophoroside from red raspberry fruits." Food Chemistry 120(4): 1131-1137. Suntres, Z. E. (2011). "Liposomal antioxidants for protection against oxidant-induced damage." Journal of toxicology 2011. Svanberg, L., K. Malmberg, G. Gustinelli, C. Öhgren, I. Persson, L. Brive and S. Wassén (2019). "Effect of anthocyanins on lipid oxidation and microbial spoilage in value-added emulsions with bilberry seed oil, anthocyanins and cold set whey protein hydrogels." Food chemistry 272: 273-278. Tabart, J., C. Auger, C. Kevers, J. Dommes, B. Pollet, J.-O. Defraigne, V. B. Schini-Kerth and J. Pincemail (2018). "The potency of commercial blackcurrant juices to induce relaxation in porcine coronary artery rings is not correlated to their antioxidant capacity but to their anthocyanin content." Nutrition 51: 53-59. Takeoka, G. R., L. T. Dao, G. H. Full, R. Y. Wong, L. A. Harden, R. H. Edwards and J. D. J. Berrios (1997). "Characterization of black bean (Phaseolus vulgaris L.) anthocyanins." Journal of Agricultural and Food Chemistry 45(9): 3395-3400. Takikawa, M., S. Inoue, F. Horio and T. Tsuda (2010). "Dietary Anthocyanin-Rich Bilberry Extract Ameliorates Hyperglycemia and Insulin Sensitivity via Activation of AMP-Activated Protein Kinase in Diabetic Mice–3." The Journal of nutrition 140(3): 527-533. Timberlake, C. and P. Bridle (1971). "The anthocyanins of apples and pears: the occurrence of acyl derivatives." Journal of the Science of Food and Agriculture 22(10): 509-513. Tsai, T.-C., H.-P. Huang, Y.-C. Chang and C.-J. Wang (2014). "An anthocyanin-rich extract from Hibiscus sabdariffa linnaeus inhibits N-nitrosomethylurea-induced leukemia in rats." Journal of agricultural and food chemistry 62(7): 1572-1580. Tsuda, T., F. Horio, K. Uchida, H. Aoki and T. Osawa (2003). "Dietary cyanidin 3-O-β-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice." The Journal of nutrition 133(7): 2125-2130. Tsuda, T., K. Shiga, K. Ohshima, S. Kawakishi and T. Osawa (1996). "Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from Phaseolus vulgaris L." Biochemical Pharmacology 52(7): 1033-1039. Türker, N. and F. Erdogˇdu (2006). "Effects of pH and temperature of extraction medium on effective diffusion coefficient of anthocynanin pigments of black carrot (Daucus carota var. L.)." Journal of Food Engineering 76(4): 579-583. Vasiliu, S., I. Bunia, S. Racovita and V. Neagu (2011). "Adsorption of cefotaxime sodium salt on polymer coated ion exchange resin microparticles: Kinetics, equilibrium and thermodynamic studies." Carbohydrate Polymers 85(2): 376-387. Villano, D., M. Fernández-Pachón, A. Troncoso and M. García-Parrilla (2006). "Influence of enological practices on the antioxidant activity of wines." Food Chemistry 95(3): 394-404. Vinson, J. A., Y. A. Dabbagh, M. M. Serry and J. Jang (1995). "Plant flavonoids, especially tea flavonols, are powerful antioxidants using an in vitro oxidation model for heart disease." Journal of Agricultural and Food Chemistry 43(11): 2800-2802. Wan, P., Sheng, Q. Han, Y. Zhao, G. Cheng and Y. Li (2014). Enrichment and purification of total flavonoids from Flos Populi extracts with macroporous resins and evaluation of antioxidant activities in vitro. Journal of Chromatography B, 945–946, 68–74. DOI: 10.1016/j.jchromb.2013.11.033. Wang, H., G. Cao and R. L. Prior (1997). "Oxygen radical absorbing capacity of anthocyanins." Journal of agricultural and Food Chemistry 45(2): 304-309. Wang, L., Y. M. Li, L. Lei, Y. Liu, X. Wang, K. Y. Ma and Z.-Y. Chen (2015). "Cranberry anthocyanin extract prolongs lifespan of fruit flies." Experimental gerontology 69: 189-195. Wang, L. and C. L. Weller (2006). "Recent advances in extraction of nutraceuticals from plants." Trends in Food Science & Technology 17(6): 300-312. Wang, L., H. Zhu, Y. Zhao, R. Jiao, L. Lei, J. Chen, X. Wang, Z. Zhang, Y. Huang and T. Wang (2018). "Cranberry anthocyanin as an herbal medicine lowers plasma cholesterol by increasing excretion of fecal sterols." Phytomedicine 38: 98-106. Wang, S. Y. and A. W. Stretch (2001). "Antioxidant capacity in cranberry is influenced by cultivar and storage temperature." Journal of Agricultural and Food Chemistry 49(2): 969-974. Wang, Z., C. Wang, J. Yuan and C. Zhang (2017). "Adsorption characteristics of adsorbent resins and antioxidant capacity for enrichment of phenolics from two-phase olive waste." Journal of Chromatography B 1040: 38-46. Wei, J., G. Zhang, X. Zhang, J. Gao, J. Fan and Z. Zhou (2016). "Anthocyanin improving metabolic disorders in obese mice from Aornia melanocarpa." Indian Journal of Pharmaceutical Education and Research 50(3): 368-375. Wei, Z., X. Qi, T. Li, M. Luo, W. Wang, Y. Zu and Y. Fu (2015). "Application of natural deep eutectic solvents for extraction and determination of phenolics in Cajanus cajan leaves by ultra performance liquid chromatography." Separation and Purification Technology 149: 237-244. Wu, Y., Y. Han, Y. Tao, S. Fan, D.-T. Chu, X. Ye, M. Ye and G. Xie (2018). "Ultrasound assisted adsorption and desorption of blueberry anthocyanins using macroporous resins." Ultrasonics sonochemistry 48: 311-320. Xia, N., A. Pautz, U. Wollscheid, G. Reifenberg, U. Förstermann and H. Li (2014). "Artichoke, cynarin and cyanidin downregulate the expression of inducible nitric oxide synthase in human coronary smooth muscle cells." Molecules 19(3): 3654-3668. Xu, B. and S. Chang (2007). "A comparative study on phenolic profiles and antioxidant activities of legumes as affected by extraction solvents." Journal of food science 72(2): S159-S166. Yang, Y., X. Yuan, Y. Xu and Z. Yu (2015). "Purification of anthocyanins from extracts of red raspberry using macroporous resin." International journal of food properties 18(5): 1046-1058. Yang, Z., Z. Chen, S. Yuan, W. Zhai, X. Piao and X. Piao (2009). "Extraction and identification of anthocyanin from purple corn (Zea mays L.)." International journal of food science & technology 44(12): 2485-2492. Yang, Z. and W. Zhai (2010). "Optimization of microwave-assisted extraction of anthocyanins from purple corn (Zea mays L.) cob and identification with HPLC–MS." Innovative food science & emerging technologies 11(3): 470-476. Yoshikura, K. and Y. Hamaguchi (1969). "Anthocyanins of black soybean." Journal of Japanese Society of Food and Nutrition 22: 367-370. Zhang, G., S. Chen, W. Zhou, J. Meng, K. Deng, H. Zhou, N. Hu and Y. Suo (2019). "Anthocyanin composition of fruit extracts from Lycium ruthenicum and their protective effect for gouty arthritis." Industrial Crops and Products 129: 414-423. ZHANG, S.-l., D. Peng, Y.-c. XU, S.-w. Lü and J.-j. WANG (2016). "Quantification and analysis of anthocyanin and flavonoids compositions, and antioxidant activities in onions with three different colors." Journal of integrative agriculture 15(9): 2175-2181. Zhang, Y., B. Jayaprakasam, N. P. Seeram, L. K. Olson, D. DeWitt and M. G. Nair (2004). "Insulin secretion and cyclooxygenase enzyme inhibition by cabernet sauvignon grape skin compounds." Journal of agricultural and food chemistry 52(2): 228-233. Zheng, X., X. Xu, C. Liu, Y. Sun, Z. Lin and H. Liu (2013). "Extraction characteristics and optimal parameters of anthocyanin from blueberry powder under microwave-assisted extraction conditions." Separation and Purification Technology 104: 17-25. Zhongdong, L., W. Guohua, G. Yunchang and J. F. Kennedy (2006). "Image study of pectin extraction from orange skin assisted by microwave." Carbohydrate polymers 64(4): 548-552. Zhu, Y., H. Song, X. Zhang, C. Chen, S. Zhao, F. Ge and D. Liu (2017). "Recovery of Flavonoids from Walnuts De‐Pellicle Wastewater with Macroporous Resins and Evaluation of Antioxidant Activities In Vitro." Journal of Food Process Engineering 40(1): e12275. Zorenc, Z., R. Veberic and M. Mikulic‐Petkovsek (2018). "Are Processed Bilberry Products a Good Source of Phenolics?" Journal of food science.por
dc.subject.cnpqCiência e Tecnologia de Alimentospor
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